Click here to close Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly. We suggest using a current version of Chrome, FireFox, or Safari.
XB-ART-28223
Science 1987 Mar 20;2354795:1489-92.
Show Gene links Show Anatomy links

Molecular cloning and expression of a human B-cell growth factor gene in Escherichia coli.

Sharma S , Mehta S , Morgan J , Maizel A .


???displayArticle.abstract???
A human B-cell growth factor (BCGF) (12 kilodaltons) supports the clonal proliferation of B lymphocytes. A clone was isolated that contained the proper structural sequence to encode biologically active, 12-kilodalton BCGF in Escherichia coli and to hybridize to a specific messenger RNA, identified by in vitro translation in Xenopus laevis oocytes. A relatively hydrophobic region of 18 amino acids was found at the amino terminal of the 124-amino acid-long polypeptide. The carboxyl terminal is composed of at least 32 amino acids that are derived from nucleotide sequences bearing significant homology to the Alu repeat family.

???displayArticle.pubmedLink??? 3547651
???displayArticle.link??? Science
???displayArticle.grants??? [+]


References :
Zietkiewicz, Phylogenetic analysis of a reported complementary DNA sequence. 1994, Pubmed