XB-ART-28040
J Exp Zool
1987 Aug 01;2432:211-5. doi: 10.1002/jez.1402430206.
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Monohydroxyeicosatetraenoic acid and leukotriene production by the inflammatory cells of Xenopus laevis.
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Ten frogs (Xenopus laevis) were injected with mixed bacteria to produce a septic peritonitis. Peritoneal inflammatory cells of eight animals were studied for monohydroxyeicosanoid and leukotriene production from exogenous arachidonic acid. Large amounts of 12-hydroxyeicosatetraenoic acid were produced; smaller amounts of 5- and 15-hydroxyeicosatetraenoic and leukotriene B4 were produced. Identifications were confirmed by retention times on HPLC, ultraviolet spectroscopy on all products, and gas chromatograph/mass spectrometry in the case of 12-hydroxyeicosatetraenoic acid.
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Species referenced: Xenopus laevis
Genes referenced: gnas