XB-ART-27804
J Recept Res
1988 Jan 01;81-4:183-93. doi: 10.3109/10799898809048986.
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Molecular cloning of the antagonist-binding subunit of the glycine receptor.
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The postsynaptic receptor for the inhibitory neurotransmitter glycine is a heterooligomeric membrane protein which, after affinity purification on an antagonist column, contains three polypeptides of 48K, 58K and 93K. Sequencing of cDNA clones of the antagonist-binding 48K subunit revealed a structural organization similar to and significant amino acid homology with nicotinic acetylcholine receptor proteins. Our data suggest the existence of a set of related genes encoding transmembrane channel-forming neurotransmitter receptor polypeptides of excitable membranes.
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