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XB-ART-27742
Histochemistry 1988 Jan 01;902:161-4. doi: 10.1007/bf00500981.
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Xenopsin immunoreactivity in antral G-cells may reside in the N-terminus of gastrin 17.

Johnston CF , Shaw C , Ardill JE , Sloan JM , Buchanan KD .


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The nature of xenopsin immunoreactivity in mammalian antral G-cells has been reassessed. Xenopsin immunostaining was most intense in human antral G-cells, present in those of the dog and pig and not detected in guinea pig or rat tissues. Rigorous specificity controls for ionic binding of immunoglobulins to antral G-cell granules indicated that this mechanism was not responsible for xenopsin immunostaining. Preincubation of the xenopsin antiserum with xenopsin, human gastrin 1-13 and gastrin 2-17 completely abolished immunostaining at similar molar concentrations. Gastrin 34 was ineffective at much higher concentrations. These results infer that xenopsin-immunoreactivity in antral G-cells resides in the N-terminal region of gastrin 17. Examination of the primary structures of xenopsin and the N-terminal regions of some mammalian gastrins reveals a hitherto unrecognized homology.

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Species referenced: Xenopus
Genes referenced: gast levi

References [+] :
Andersen, Species variation in the tyrosine sulfation of mammalian gastrins. 1985, Pubmed