Cell Differ 1988 Jun 01;241:33-43. doi: 10.1016/0045-6039(88)90084-x.

Close juxtaposition between inducing chordamesoderm and reacting neuroectoderm is a prerequisite for neural induction in Xenopus laevis.

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The results of this study indicate that the induction of the central nervous system in Xenopus laevis depends on the close juxtaposition of inducing chordamesoderm and reacting ectoderm, which is necessary for the short distance migration of neural inducing factors. The examination of the neuroectoderm-chordamesoderm interface at intervals of 1 h up to 5 h showed that the onset of neural induction is correlated to the degree of contact formation between ectodermal and mesodermal cells. In the ectoderm cells the number of coated pits, a feature of receptor-mediated endocytosis, is increased. Furthermore there exist telophase bridges between some ectoderm cells, which are possibly correlated to secondary cell interactions.

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