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XB-ART-27007
Dev Comp Immunol 1989 Jan 01;132:159-66.
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Differential cyclophosphamide sensitivity of suppressor function in Xenopus, the clawed toad.

Clothier RH , Last Z , Somauroo JD , Ruben LN , Balls M .


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Thymocyte and Splenocyte cultures from in vivo immunised Xenopus were assayed to test their suppressive capacity. Immunisation with TNP-Polyvinylpyrrolidone induced suppression. Suppression induced by the haptenated antigens, TNP-Red blood cells, TNP-Lipopolysaccharide, and TNP-Ficoll affected the anti-TNP antibody response of splenocytes from TNP-PVP immunised animals. Pretreatment with cyclophosphamide revealed both a sensitive and insensitive suppression capacity in Xenopus laevis.

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