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XB-ART-26753
Eur J Pharmacol 1989 May 30;1643:599-602. doi: 10.1016/0014-2999(89)90272-0.
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Effects of THA on ionic currents in myelinated axons of Xenopus laevis.

Elinder F , Mohammed AK , Winblad B , Arhem P .


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In voltage-clamp experiments with the myelinated nerve fibre of Xenopus laevis, 9-amino-1,2,3,4-tetrahydroacridine (THA) decreased both Na+ and K+ currents and shifted the steady state inactivation potential curve in a negative direction. The effects may be described as (a) a decrease of the permeability constant PNa, (b) a modified potential dependence of the inactivating system and (c) a decrease of PK. The Na+ system was affected more than the K+ system.

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