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XB-ART-26582
Biochem Biophys Res Commun 1989 Aug 15;1623:1535-40.
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E-series prostaglandins activate cAMP-mediated potassium currents in follicle-enclosed Xenopus oocyte.

Mori K , Oka S , Tani A , Ito S , Watanabe Y .


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Receptor-mediated responses to prostaglandins E1 and E2 are shown by electrophysiological methods in follicle-enclosed oocytes of Xenopus laevis. In voltage-clamped oocytes, prostaglandins E1 and E2 elicited an outward hyperpolarizing current. This outward membrane current was caused by an increase in K+ conductance. The prostaglandin-induced current was augmented by adenylate cyclase activator, forskolin, and by phosphodiesterase inhibitor, theophylline, indicating that adenosine 3', 5'-cyclic monophosphate (cAMP) is involved in activating the K+ current. The prostaglandin responses were either abolished or greatly reduced by removing follicular cells with collagenase, suggesting that prostaglandin receptors reside in the follicular cells.

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Genes referenced: camp