Click here to close
Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly.
We suggest using a current version of Chrome,
FireFox, or Safari.
Proc Natl Acad Sci U S A
1989 Sep 01;8617:6597-601.
Show Gene links
Show Anatomy links
Magainins and the disruption of membrane-linked free-energy transduction.
Westerhoff HV
,
Jureti D
,
Hendler RW
,
Zasloff M
.
???displayArticle.abstract??? Magainins, a family of positively charged peptides, are partly if not wholly responsible for antimicrobial activity in skin extracts of Xenopus laevis. We report here that members of the magainin family--i.e., the 21-amino acid peptide PGLa and the 23-amino acid peptide magainin 2 amide (PGSa)--dissipate the electric potential across various energy-transducing membranes and thus uncouple respiration from other free-energy-requiring processes. We propose that this is a likely mechanism for the antimicrobial effects of these compounds.
Ando,
Inhibitory effect of sarcotoxin IIA, an antibacterial protein of Sarcophaga peregrina, on growth of Escherichia coli.
1988, Pubmed
Ando,
Inhibitory effect of sarcotoxin IIA, an antibacterial protein of Sarcophaga peregrina, on growth of Escherichia coli.
1988,
Pubmed
Andreu,
Solid-phase synthesis of PYLa and isolation of its natural counterpart, PGLa [PYLa-(4-24)] from skin secretion of Xenopus laevis.
1985,
Pubmed
,
Xenbase
Boman,
Cell-free immunity in insects.
1987,
Pubmed
Boman,
Cell-surface alterations in Escherichia coli K-12 with chromosmal mutations changing ampicillin resistance.
1971,
Pubmed
Carroll,
Antibacterial peptide from normal rabbit serum. 3. Inhibition of microbial electron transport.
1981,
Pubmed
Chen,
Synthetic magainin analogues with improved antimicrobial activity.
1988,
Pubmed
,
Xenbase
Christensen,
Channel-forming properties of cecropins and related model compounds incorporated into planar lipid membranes.
1988,
Pubmed
Cramer,
The membrane channel-forming bacteriocidal protein, colicin El.
1983,
Pubmed
Gibson,
Novel peptide fragments originating from PGLa and the caerulein and xenopsin precursors from Xenopus laevis.
1986,
Pubmed
,
Xenbase
Giovannini,
Biosynthesis and degradation of peptides derived from Xenopus laevis prohormones.
1987,
Pubmed
,
Xenbase
Helgerson,
Changes in Escherichia coli cell envelope structure and the sites of fluorescence probe binding caused by carbonyl cyanide p-trifluoromethoxyphenylhydrazone.
1977,
Pubmed
Juretić,
Magainin 2 amide and analogues. Antimicrobial activity, membrane depolarization and susceptibility to proteolysis.
1989,
Pubmed
,
Xenbase
Kaiser,
Peptides with affinity for membranes.
1987,
Pubmed
Kamo,
Membrane potential of mitochondria measured with an electrode sensitive to tetraphenyl phosphonium and relationship between proton electrochemical potential and phosphorylation potential in steady state.
1979,
Pubmed
Kempf,
Voltage-dependent trans-bilayer orientation of melittin.
1982,
Pubmed
Kraayenhof,
Interaction between uncouplers and substrates in rat-liver mitochondria.
1969,
Pubmed
Lear,
Synthetic amphiphilic peptide models for protein ion channels.
1988,
Pubmed
Lehrer,
Oxygen-independent bactericidal systems. Mechanisms and disorders.
1988,
Pubmed
Lehrer,
Concurrent assessment of inner and outer membrane permeabilization and bacteriolysis in E. coli by multiple-wavelength spectrophotometry.
1988,
Pubmed
MITCHELL,
Coupling of phosphorylation to electron and hydrogen transfer by a chemi-osmotic type of mechanism.
1961,
Pubmed
Marion,
A two-dimensional NMR study of the antimicrobial peptide magainin 2.
1988,
Pubmed
,
Xenbase
NISHIMURA,
Studies on bacterial photophosphorylation. III. A sensitive and rapid method of determination of photophosphorylation.
1962,
Pubmed
Okada,
Mode of action of a bactericidal protein induced in the haemolymph of Sarcophaga peregrina (flesh-fly) larvae.
1984,
Pubmed
Okada,
Ionophore activity of sarcotoxin I, a bactericidal protein of Sarcophaga peregrina.
1985,
Pubmed
Padan,
Respiratory control and the proton electrochemical gradient in mitochondria.
1973,
Pubmed
Padan,
The proton electrochemical gradient in Escherichia coli cells.
1976,
Pubmed
Pedersen,
Preparation and characterization of mitochondria and submitochondrial particles of rat liver and liver-derived tissues.
1978,
Pubmed
Pietrobon,
Effect of funiculosin and antimycin A on the redox-driven H+-pumps in mitochondria: on the nature of "leaks'.
1981,
Pubmed
Ramos,
The electrochemical gradient of protons and its relationship to active transport in Escherichia coli membrane vesicles.
1976,
Pubmed
Reynafarje,
Proton translocation stoichiometry of cytochrome oxidase: use of a fast-responding oxygen electrode.
1982,
Pubmed
Rottenberg,
Membrane potential and surface potential in mitochondria: uptake and binding of lipophilic cations.
1984,
Pubmed
Selsted,
Purification and antibacterial activity of antimicrobial peptides of rabbit granulocytes.
1984,
Pubmed
Setty,
Simultaneous measurements of proton motive force, delta pH, membrane potential, and H+/O ratios in intact Escherichia coli.
1983,
Pubmed
Soravia,
Antimicrobial properties of peptides from Xenopus granular gland secretions.
1988,
Pubmed
,
Xenbase
Terry,
The cDNA sequence coding for prepro-PGS (prepro-magainins) and aspects of the processing of this prepro-polypeptide.
1988,
Pubmed
,
Xenbase
Westerhoff,
Interactions between a new class of eukaryotic antimicrobial agents and isolated rat liver mitochondria.
1989,
Pubmed
,
Xenbase
Zasloff,
Magainins, a class of antimicrobial peptides from Xenopus skin: isolation, characterization of two active forms, and partial cDNA sequence of a precursor.
1987,
Pubmed
,
Xenbase
Zasloff,
Antimicrobial activity of synthetic magainin peptides and several analogues.
1988,
Pubmed
,
Xenbase
