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J Mol Evol
1989 Oct 01;294:344-54. doi: 10.1007/bf02103621.
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Amphibian albumins as members of the albumin, alpha-fetoprotein, vitamin D-binding protein multigene family.
Haefliger DN
,
Moskaitis JE
,
Schoenberg DR
,
Wahli W
.
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The Xenopus laevis 68-kd and 74-kd albumin amino acid sequences are examined with respect to their relationship to the other known members of the albumin/alpha-fetoprotein/vitamin D-binding protein gene family. Each of the three members of this family presents a unique pattern of conserved regions indicating a differential selective pressure related to specific functional characteristics. Furthermore, an evolutionary tree of these genes was deduced from the divergence times calculated from direct nucleotide sequence comparisons of individual gene pairs. These calculations indicate that the vitamin D-binding protein/albumin separation occurred 560-600 million years (Myr) ago and the albumin/alpha-fetoprotein divergence 280 Myr ago. This observation leads to the hypothesis according to which the albumin/alpha-fetoprotein gene duplication occurred shortly after the amphibian/reptile separation. Consequently, and unlike mammals, amphibians and fishes should lack an alpha-fetoprotein in their serum at larval stages, which is consistent with a recent analysis of serum proteins in Xenopus laevis larvae. This hypothesis now will have to be tested further in additional lower vertebrates.
Alexander,
Evolution of the albumin: alpha-fetoprotein ancestral gene from the amplification of a 27 nucleotide sequence.
1984, Pubmed
Alexander,
Evolution of the albumin: alpha-fetoprotein ancestral gene from the amplification of a 27 nucleotide sequence.
1984,
Pubmed
Bisbee,
Albumin phylogeny for clawed frogs (Xenopus).
1977,
Pubmed
,
Xenbase
Brown,
Structural origins of mammalian albumin.
1976,
Pubmed
Cooke,
Rat vitamin D binding protein. Determination of the full-length primary structure from cloned cDNA.
1986,
Pubmed
Dugaiczyk,
Nucleotide sequence and the encoded amino acids of human serum albumin mRNA.
1982,
Pubmed
Efstratiadis,
The structure and evolution of the human beta-globin gene family.
1980,
Pubmed
Eiferman,
Intragenic amplification and divergence in the mouse alpha-fetoprotein gene.
1981,
Pubmed
Germond,
Evolution of vitellogenin genes: comparative analysis of the nucleotide sequences downstream of the transcription initiation site of four Xenopus laevis and one chicken gene.
1984,
Pubmed
,
Xenbase
Gibbs,
Origin of structural domains of the serum-albumin gene family and a predicted structure of the gene for vitamin D-binding protein.
1987,
Pubmed
Goad,
Pattern recognition in nucleic acid sequences. I. A general method for finding local homologies and symmetries.
1982,
Pubmed
Goodman,
Darwinian evolution in the genealogy of haemoglobin.
1975,
Pubmed
Gorin,
The evolution of alpha-fetoprotein and albumin. I. A comparison of the primary amino acid sequences of mammalian alpha-fetoprotein and albumin.
1981,
Pubmed
Graf,
Albumin evolution in polyploid species of the genus Xenopus.
1986,
Pubmed
,
Xenbase
Harper,
Linkage of the evolutionarily-related serum albumin and alpha-fetoprotein genes within q11-22 of human chromosome 4.
1983,
Pubmed
Hood,
The organization, expression, and evolution of antibody genes and other multigene families.
1975,
Pubmed
Hosbach,
The Xenopus laevis globin gene family: chromosomal arrangement and gene structure.
1983,
Pubmed
,
Xenbase
Ingram,
alpha-Fetoprotein and albumin genes are in tandem in the mouse genome.
1981,
Pubmed
Innis,
alpha-Fetoprotein gene expression. Partial DNA sequence and COOH-terminal homology to albumin.
1980,
Pubmed
Jagodzinski,
Sequence homology between RNAs encoding rat alpha-fetoprotein and rat serum albumin.
1981,
Pubmed
Kanehisa,
Los Alamos sequence analysis package for nucleic acids and proteins.
1982,
Pubmed
Kioussis,
The evolution of alpha-fetoprotein and albumin. II. The structures of the alpha-fetoprotein and albumin genes in the mouse.
1981,
Pubmed
Knöchel,
Globin evolution in the genus Xenopus: comparative analysis of cDNAs coding for adult globin polypeptides of Xenopus borealis and Xenopus tropicalis.
1986,
Pubmed
,
Xenbase
Lauer,
The chromosomal arrangement of human alpha-like globin genes: sequence homology and alpha-globin gene deletions.
1980,
Pubmed
Law,
Homology between the primary structure of alpha-fetoprotein, deduced from a complete cDNA sequence, and serum albumin.
1981,
Pubmed
Lawn,
The sequence of human serum albumin cDNA and its expression in E. coli.
1981,
Pubmed
Lindgren,
Identification and isolation of a foetoprotein in the chicken.
1974,
Pubmed
May,
Structure and evolution of the Xenopus laevis albumin genes.
1983,
Pubmed
,
Xenbase
Morinaga,
Primary structures of human alpha-fetoprotein and its mRNA.
1983,
Pubmed
Moskaitis,
Xenopus laevis serum albumin: sequence of the complementary deoxyribonucleic acids encoding the 68- and 74-kilodalton peptides and the regulation of albumin gene expression by thyroid hormone during development.
1989,
Pubmed
,
Xenbase
Nardelli,
Comparison of the organization and fine structure of a chicken and a Xenopus laevis vitellogenin gene.
1987,
Pubmed
,
Xenbase
Needleman,
A general method applicable to the search for similarities in the amino acid sequence of two proteins.
1970,
Pubmed
Perler,
The evolution of genes: the chicken preproinsulin gene.
1980,
Pubmed
Peters,
Serum albumin: recent progress in the understanding of its structure and biosynthesis.
1977,
Pubmed
Romero-Herrera,
Molecular evolution of myoglobin and the fossil record: a phylogenetic synthesis.
1973,
Pubmed
Sargent,
Nucleotide sequence of cloned rat serum albumin messenger RNA.
1981,
Pubmed
Schoenberg,
Albumin is encoded by 2 messenger RNAs in Xenopus laevis.
1981,
Pubmed
,
Xenbase
Schoentgen,
Complete amino acid sequence of human vitamin D-binding protein (group-specific component): evidence of a three-fold internal homology as in serum albumin and alpha-fetoprotein.
1986,
Pubmed
Schorpp,
5'-flanking and 5'-proximal exon regions of the two Xenopus albumin genes. Deletion analysis of constitutive promoter function.
1988,
Pubmed
,
Xenbase
Smith,
Evolution of repeated DNA sequences by unequal crossover.
1976,
Pubmed
Szpirer,
Gene mapping in the rat by mouse-rat somatic cell hybridization: synteny of the albumin and alpha-fetoprotein genes and assignment to chromosome 14.
1984,
Pubmed
Tilghman,
The structure and regulation of the alpha-fetoprotein and albumin genes.
1985,
Pubmed
Turcotte,
Rat alpha 1-fetoprotein messenger RNA: 5'-end sequence and glucocorticoid-suppressed liver transcription in an improved nuclear run-off assay.
1985,
Pubmed
Urano,
Tandem arrangement of the albumin and alpha-fetoprotein genes in the human genome.
1984,
Pubmed
Wahli,
Retention of the differentiated state by larvalXenopus liver cells in primary culture.
1978,
Pubmed
,
Xenbase
Wahli,
Vitellogenin in Xenopus laevis is encoded in a small family of genes.
1979,
Pubmed
,
Xenbase
Westley,
Xenopus laevis serum albumins are encoded in two closely related genes.
1981,
Pubmed
,
Xenbase
Westley,
Divergence of the two albumins of X. laevis. Evidence for the glycosylation of the major 74K albumin.
1982,
Pubmed
,
Xenbase
Wilbur,
Rapid similarity searches of nucleic acid and protein data banks.
1983,
Pubmed
Wilson,
Biochemical evolution.
1977,
Pubmed
Yang,
Evolutionary and structural relationships among the group-specific component, albumin and alpha-fetoprotein.
1985,
Pubmed
