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Histochemistry
1990 Jan 01;952:137-41. doi: 10.1007/bf00266585.
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Characterization of MSH/ACTH-like immunoreactivity in sciatic nerves of Xenopus laevis by immunocytochemistry, western blotting and radioimmunoassay.
Tingstedt JE
,
Nielsen JB
,
Larsson LI
.
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Previous studies have indicated that rat neurofilament protein may contain an endogenous MSH-like epitope with neuroregenerative properties. The presence of such an epitope has now been studied in nervetissue from Xenopus laevis. Western blot analyses of sciatic nervetissue using an assortment of sequence-specific MSH/ACTH antisera revealed the presence of two major immunoreactive protein bands of 52 and 50 kDa, which contained a mid-region MSH-like epitope. Weaker staining occurred in another protein band at 135 kDa. Immunocytochemistry revealed the immunoreactivity to reside in the axis cylinders of the nerve fibers. Other antisera, recognizing other regions of MSH/ACTH produced strong staining of Xenopus intermediate lobes, but failed to stain sciatic nerves. Thus, the proteins detected have no clear relation to either Xenopus neurofilament proteins or proopiomelanocortin.
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Stimulation by ACTH4-10 of nerve fiber regeneration following sciatic nerve crush.
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Neurofilaments contain alpha-melanocyte-stimulating hormone (alpha-MSH)-like immunoreactivity.
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Edwards,
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Characterization of immunoreactive proopiomelanocortin-related peptides in rat testes.
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Expression of two proopiomelanocortin genes in the pituitary gland of Xenopus laevis: complete structures of the two preprohormones.
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ACTH/MSH 4-10 improves motor unit reorganization during peripheral nerve regeneration in the rat.
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