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XB-ART-26237
Enzyme 1990 Jan 01;441-4:193-202. doi: 10.1159/000468757.
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Translational control mediated by UA-rich sequences.

Kruys V , Beutler B , Huez G .


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Several messenger RNAs coding for cytokines, growth factors or oncoproteins contain a conserved UA-rich sequence in their 3' untranslated regions. This sequence, which is composed of several interspersed repeats of the octanucleotide UUAUUUAU, is a key element in the posttranscriptional regulation of these mRNAs. Previously shown to be involved in mRNA destabilization, these UA-rich elements can also strongly influence mRNA translation. A translation inhibition mediated by these sequences has indeed been observed in vitro as well as in frog oocyte or in somatic cells.

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