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XB-ART-26145
FEBS Lett 1990 Jan 15;2601:149-51.
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Inactivation of cGMP-dependent conductance of rod outer segment plasma membrane induced by cGMP.

Zhainazarov AB , Kolesnikov SS .


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Integral cGMP-dependent currents as well as activity of single cGMP-activated channels in plasma membrane of rod outer segment (ROS) were recorded using the patch-clamp method. The dependence of integral currents on cGMP concentration is shown to be bell-shaped. Decrease in cGMP-dependent conductance at high cGMP concentration results from a decrease in channel opening probability. Thus, cGMP in high concentrations inactivates cGMP-dependent conductance.

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