Pigment Cell Res 1990 Jan 01;32:101-14. doi: 10.1111/j.1600-0749.1990.tb00329.x.

Studies on cellular adhesion of Xenopus laevis melanophores: pigment pattern formation and alteration in vivo by endogenous galactoside-binding lectin or its sugar hapten inhibitor.

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We have studied the development of Xenopus laevis tail melanophores and the effects on these cells on confrontation with endogenous X. laevis galactoside-binding lectin or its sugar hapten inhibitor thiodigalactoside (TDG). An initial population of unpigmented cells differentiates into melanophores on the dorsal surface of the neural tube, and on the dorsal and ventral apices of the myotomes, forming the larval pattern. Melanophores secondarily populate the flank, forming a spaced arrangement which is later transformed into a dorsal and ventral strip. A technique has been developed for confrontation of premigratory neural crest with purified lectin or TDG. These molecules impact on tail melanophores. With lectin treatment melanophore numbers decrease, and cell morphologies and arrangements change. TDG treatment, however, primarily affects pigment cell morphology. These results suggest that both galactoside-bearing receptors for this lectin and the lectin itself can affect melanophores in this species of frog.

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Species referenced: Xenopus laevis
Genes referenced: tdg