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XB-ART-25983
Mol Cell Biol 1990 Apr 01;104:1815-7. doi: 10.1128/mcb.10.4.1815-1817.1990.
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brlA requires both zinc fingers to induce development.

Adams TH , Deising H , Timberlake WE .


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Expression of the Aspergillus nidulans brlA gene induces a developmental pathway leading to the production of asexual spores. We have introduced mutations into brlA that are expected to disrupt either or both Cys2-His2 Zn(II) coordination sites postulated to exist in the BrlA polypeptide. The resultant brlA alleles fail to induce either the asexual reproductive pathway or the expression of development-specific genes. These data support the hypothesis that brlA encodes a nucleic acid-binding protein whose activity requires each of two zinc fingers.

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References [+] :
Adams, brlA is necessary and sufficient to direct conidiophore development in Aspergillus nidulans. 1988, Pubmed, Xenbase