XB-ART-25806
FEBS Lett
1990 Jun 18;2661-2:142-6.
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Metal ion co-ordination in the DNA binding domain of the yeast transcriptional activator GAL4.
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The structure of the DNA binding domain of the yeast transcriptional activator GAL4 was investigated by extended X-ray fine structure (e.x.a.f.s.). Two samples of GAL4 were studied, one containing cadmium as a structural probe (Cd(II)GAL4) and the other containing the 'native' zinc (Zn(II)-GAL4). The results suggest that the structure of the DNA binding domain of GAL4 contains a two metal ion cluster distinguishing it from the 'zinc finger' proteins typified by the Xenopus laevis transcription factor TFIIIA.
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Species referenced: Xenopus laevis
Genes referenced: gtf3a lgals4.2