Click here to close Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly. We suggest using a current version of Chrome, FireFox, or Safari.
XB-ART-25656
Glycobiology 1990 Sep 01;11:39-44. doi: 10.1093/glycob/1.1.39.
Show Gene links Show Anatomy links

Expression of beta-galactoside alpha 2,6 sialyltransferase blocks synthesis of polysialic acid in Xenopus embryos.

Livingston BD , De Robertis EM , Paulson JC .


???displayArticle.abstract???
Polysialic acid is a developmentally regulated carbohydrate structure found on neural cell adhesion molecules (NCAM). Expression of beta-galactoside alpha 2,6-sialyltransferase in Xenopus embryos, by injection of mRNA, prevents the polysialylation of NCAM, presumably by introducing a different type of sugar linkage that terminates chain elongation. Abnormalities in neural development result from this treatment, but in general the body plan of the injected embryos is not severely affected. The results provide evidence that the mis-expression of glycosyltransferases can be used to interfere with the normal pattern of glycosylation in whole organisms.

???displayArticle.pubmedLink??? 2136379
???displayArticle.link??? Glycobiology
???displayArticle.grants??? [+]

Species referenced: Xenopus
Genes referenced: ncam1