Gen Comp Endocrinol 1991 Jan 01;811:28-38. doi: 10.1016/0016-6480(91)90122-m.

The effects of photoperiod and different dosages of melatonin on metamorphic rate and weight gain in Xenopus laevis tadpoles.

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This study examined the effects of photoperiod and three different dosages of melatonin on the rate of metamorphosis and weight gain in Xenopus laevis. Exposure of larvae to 23L:1D resulted in lower mean body weight and a retarded metamorphic rate in comparison to larvae exposed to 1L:23D. Larvae reared in either photoperiod and treated with exogenous melatonin demonstrated a dose-dependent suppression of weight attained, with short photoperiod larvae showing a more dramatic effect. Analysis of growth patterns indicate that photoperiod and exogenous melatonin have a greater effect on weights prior to Nieuwkoop and Faber stage 56 in the development of Xenopus. Larvae exposed to 1L:23D and exogenous melatonin metamorphosed at an accelerated rate when compared to larvae exposed to 23L:1D and the same dosages of melatonin. In both photoperiod regimens an exogenous melatonin concentration of 45 micrograms/100 ml resulted in an accelerated metamorphic rate, whereas 225 and 450 micrograms/100 ml retarded metamorphic rate of larvae in comparison to controls.

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Species referenced: Xenopus laevis
Genes referenced: prl.1 thra tshb