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XB-ART-25126
Eur J Pharmacol 1991 Jan 25;2061:77-80. doi: 10.1016/0922-4106(91)90149-c.
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Effects of subunit types of the cloned GABAA receptor on the response to a neurosteroid.

Shingai R , Sutherland ML , Barnard EA .


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Combinations of cloned GABAA receptor subtypes, having the subunit combinations alpha i + beta 1 or alpha i + beta 1 + gamma 2 (i = 1, 2, 3), were expressed in Xenopus oocytes. The endogenous steroid 3 alpha-hydroxy-5 alpha-pregnan-20-one potentiates GABA currents induced therein by GABA. This potentiation was greater in the alpha 1 + beta and alpha 3 + beta 1 than in the alpha 2 + beta 1 combinations. The presence of the gamma 2-subunit increased the steroid potency in alpha 1 + beta 1 and alpha 2 + beta 1, but the combination alpha 3 + beta 1 + gamma 2 became much less steroid-sensitive. It is concluded that the steroid modification of the GABAA receptor is strongly influenced by the alpha- and the gamma 2-subunit types.

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Species referenced: Xenopus
Genes referenced: gabarap