Click here to close Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly. We suggest using a current version of Chrome, FireFox, or Safari.
XB-ART-24692
FEBS Lett 1991 Jul 22;2852:189-93.
Show Gene links Show Anatomy links

The functional role of the beta-subunit in the maturation and intracellular transport of Na,K-ATPase.

Geering K .


???displayArticle.abstract???
The minimal functional enzyme unit of Na,K-ATPase consists of an alpha-beta complex. The alpha-subunit bears all functional domains of the enzyme and so far a regulatory role for the beta-subunit in the catalytic cycle has not been established. On the other hand, increasing experimental evidence suggests that the beta-subunit is an indispensable element for the structural and functional maturation of the enzyme as well as its intracellular transport to the plasma membrane. This brief review summarizes the experimental data supporting the hypothesis that assembly of the beta-subunit is needed for the alpha-subunit to acquire the correct, stable configuration necessary for the acquisition of functional properties and its exit from the ER.

???displayArticle.pubmedLink??? 1649770
???displayArticle.link??? FEBS Lett


Species referenced: Xenopus
Genes referenced: atp1a1