Click here to close Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly. We suggest using a current version of Chrome, FireFox, or Safari.
XB-ART-24498
J Neurosci Res 1991 Oct 01;302:316-20. doi: 10.1002/jnr.490300206.
Show Gene links Show Anatomy links

Histamine effects on the 5-HT1c receptor expressed in Xenopus oocytes.

Shichijo S , Payan DG , Harrowe G , Mitsuhashi M .


???displayArticle.abstract???
To analyze the cross-reactivity between serotonin (5-HT) and histamine, the in vitro transcribed RNA for the 5-HT1c receptor was functionally expressed in Xenopus oocytes. 5-HT significantly increased 45Ca2+ efflux in RNA-injected oocytes, but not in uninjected and water-injected control oocytes. Furthermore, histamine and the H1 receptor agonists, but not the H2 and H3 agonists, significantly induced 45Ca2+ efflux in 5-HT1c receptor RNA-injected oocytes, but not in uninjected and water-injected oocytes. However, the H1, H2, and H3 antagonists failed to inhibit histamine-induced 45Ca2+ efflux at 10(-6) M. This finding suggests that the 5-HT1c receptor can be activated by both 5-HT and histamine, although the action of histamine is different from classic histamine pharmacology.

???displayArticle.pubmedLink??? 1724674
???displayArticle.link??? J Neurosci Res
???displayArticle.grants??? [+]