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XB-ART-24215
Acta Physiol Scand Suppl 1992 Jan 01;607:177-81.
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Subunit assembly and posttranslational processing of Na(+)-pumps.

Geering K .


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Assembly, posttranslational processing and intracellular transport of Na,K-ATPase subunits are closely linked processes. Only coexpression of alpha- and beta-subunits in Xenopus oocytes permits the structural maturation and the ER exit of the two subunits. A putative beta 3-isoform of Na,K-ATPase and the beta-subunit of H,K-ATPase can support similar functions to those of beta 1-subunits of Na,K-ATPase in allowing the functional expression of alpha-beta complexes with Na,K-pump transport properties in the plasma membrane. These data indicate that a primary role of the beta subunit is to impose a conformational change on the newly synthesized alpha-subunits probably involved in the acquisition of transport competence and functional maturity of the catalytic alpha-subunit.

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Species referenced: Xenopus
Genes referenced: atp1a1