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XB-ART-24169
Eur Biophys J 1992 Jan 01;212:93-7. doi: 10.1007/bf00185424.
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The effect of phloretin on single potassium channels in myelinated nerve.

Klusemann J , Meves H .


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The effect of phloretin, a dipolar organic compound, on single potassium channel currents of myelinated nerve fibres of Xenopus laevis has been investigated, using inside-out patches prepared by the method of Jonas et al. (1989). The I channel, a potential dependent K channel with intermediate deactivation kinetics, was reversibly blocked by 20 microM phloretin applied on the inside; the block was strongest at negative membrane potentials and less pronounced at positive potentials. Phloretin shifted the curve relating open probability to membrane potential towards more positive potentials and reduced its slope and maximum. This confirms previous findings on the effect of phloretin on the voltage dependence of the fast macroscopic K conductance. Single channel conductance and deactivation kinetics were not altered by phloretin.

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Species referenced: Xenopus laevis
Genes referenced: tbx2

References [+] :
Dubois, Evidence for the existence of three types of potassium channels in the frog Ranvier node membrane. 1981, Pubmed