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Angiotensin II and acetylcholine differentially activate mobilization of inositol phosphates in Xenopus laevis ovarian follicles.
Lacy P
,
Murray-McIntosh RP
,
McIntosh JE
.
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Angiotensin II (AII) evokes a Ca(2+)-dependent Cl- current in Xenopus laevis ovarian follicles that appears to involve a pertussis-toxin-sensitive G protein mediating phosphoinositide hydrolysis and Ca2+ mobilization from intracellular stores. Follicle responses to AII closely resemble the two-component response stimulated by acetylcholine (ACh) in this tissue. Intraoocyte injections of phytic acid, heparin, and inositol 1,4,5-trisphosphate [Ins(1,4,5)P3], acting as inhibitors of Ins(1,4,5)P3-induced Ca(2+)-release, resulted in loss of responsiveness to AII and ACh. As previously reported for ACh [Moriarty et al. (1988) Proc Natl Acad Sci USA 85: 8865-8869], pertussis toxin and microinjected GTP[gammaS] were found to inhibit follicle responses to AII, implying the involvement of a G protein. However, ACh and AII responses differ strikingly in the way they mobilize inositol phosphates and in densitization characteristics. We have previously been unable to find significant increases in inositol phosphates after 60 min stimulation (with Li+) by AII, although ACh potently activated increases in these [McIntosh and McIntosh (1990) Arch Biochem Biophys 283: 135-140]. In the present paper, AII was found to activate rapid increases in inositol bis- and trisphosphates after 1 min stimulation without Li+. ACh and AII also exerted different actions on follicle adenylate-cyclase-dependent responses. We conclude that at least two separate inositol-phosphate-linked receptor mechanisms may exist in ovarian follicles, resulting from involvement of one or more pertussis-toxin-sensitive G protein(s).
Barish,
A transient calcium-dependent chloride current in the immature Xenopus oocyte.
1983, Pubmed,
Xenbase
Barish,
A transient calcium-dependent chloride current in the immature Xenopus oocyte.
1983,
Pubmed
,
Xenbase
Berridge,
Inositol 1,4,5-trisphosphate-induced calcium mobilization is localized in Xenopus oocytes.
1989,
Pubmed
,
Xenbase
Berridge,
Changes in the levels of inositol phosphates after agonist-dependent hydrolysis of membrane phosphoinositides.
1983,
Pubmed
Cockcroft,
Role of guanine nucleotide binding protein in the activation of polyphosphoinositide phosphodiesterase.
,
Pubmed
Cormier,
Involvement of protein kinase A and casein kinase II in the in vivo protein kinase activities in prophase arrested Xenopus oocytes.
1989,
Pubmed
,
Xenbase
Dascal,
Acetylcholine and phorbol esters inhibit potassium currents evoked by adenosine and cAMP in Xenopus oocytes.
1985,
Pubmed
,
Xenbase
Dascal,
Role of calcium mobilization in mediation of acetylcholine-evoked chloride currents in Xenopus laevis oocytes.
1985,
Pubmed
,
Xenbase
Dascal,
Involvement of a GTP-binding protein in mediation of serotonin and acetylcholine responses in Xenopus oocytes injected with rat brain messenger RNA.
1986,
Pubmed
,
Xenbase
Dascal,
Xenopus oocyte resting potential, muscarinic responses and the role of calcium and guanosine 3',5'-cyclic monophosphate.
1984,
Pubmed
,
Xenbase
Dascal,
The use of Xenopus oocytes for the study of ion channels.
1987,
Pubmed
,
Xenbase
Downes,
Inositol 1,3,4,5-tetrakisphosphate and not phosphatidylinositol 3,4-bisphosphate is the probable precursor of inositol 1,3,4-trisphosphate in agonist-stimulated parotid gland.
1986,
Pubmed
Ghosh,
Competitive, reversible, and potent antagonism of inositol 1,4,5-trisphosphate-activated calcium release by heparin.
1988,
Pubmed
Gillo,
The involvement of inositol 1,4,5-trisphosphate and calcium in the two-component response to acetylcholine in Xenopus oocytes.
1987,
Pubmed
,
Xenbase
Guillemette,
Differential effects of heparin on inositol 1,4,5-trisphosphate binding, metabolism, and calcium release activity in the bovine adrenal cortex.
1989,
Pubmed
Husain,
Localization of angiotensin II receptors in ovarian follicles and the identification of angiotensin II in rat ovaries.
1987,
Pubmed
Kurose,
Functional interaction of purified muscarinic receptors with purified inhibitory guanine nucleotide regulatory proteins reconstituted in phospholipid vesicles.
1986,
Pubmed
Kusano,
Cholinergic and catecholaminergic receptors in the Xenopus oocyte membrane.
1982,
Pubmed
,
Xenbase
Lacy,
Angiotensin II stimulates an endogenous response in Xenopus laevis ovarian follicles.
1989,
Pubmed
,
Xenbase
Lechleiter,
Subcellular patterns of calcium release determined by G protein-specific residues of muscarinic receptors.
1991,
Pubmed
,
Xenbase
McIntosh,
Diversity in responses from endogenous and expressed mammalian receptors which cause chloride ion efflux from ovarian follicles of Xenopus laevis.
1990,
Pubmed
,
Xenbase
McIntosh,
Metabolism of the biologically active inositol phosphates Ins(1,4,5)P3 and Ins(1,3,4,5)P4 by ovarian follicles of Xenopus laevis.
1990,
Pubmed
,
Xenbase
McIntosh,
Formation of inositol pentakisphosphate by ovarian follicles of Xenopus laevis from metabolism of inositol (1,4,5)trisphosphate and inositol (1,3,4,5)tetrakisphosphate and from receptor activation.
1990,
Pubmed
,
Xenbase
McIntosh,
Coupling of inositol phospholipid hydrolysis to peptide hormone receptors expressed from adrenal and pituitary mRNA in Xenopus laevis oocytes.
1987,
Pubmed
,
Xenbase
Miledi,
A calcium-dependent transient outward current in Xenopus laevis oocytes.
1982,
Pubmed
,
Xenbase
Moriarty,
Beta gamma subunits of GTP-binding proteins inhibit muscarinic receptor stimulation of phospholipase C.
1988,
Pubmed
,
Xenbase
Nadler,
Acetylcholine- and inositol 1,4,5-trisphosphate-induced calcium mobilization in Xenopus laevis oocytes.
1986,
Pubmed
,
Xenbase
Nomura,
Inositol phosphate formation and chloride current responses induced by acetylcholine and serotonin through GTP-binding proteins in Xenopus oocyte after injection of rat brain messenger RNA.
1987,
Pubmed
,
Xenbase
Oron,
Inositol 1,4,5-trisphosphate mimics muscarinic response in Xenopus oocytes.
,
Pubmed
,
Xenbase
Oron,
Mechanism of membrane electrical response to thyrotropin-releasing hormone in Xenopus oocytes injected with GH3 pituitary cell messenger ribonucleic acid.
1987,
Pubmed
,
Xenbase
Palade,
Pharmacologic differentiation between inositol-1,4,5-trisphosphate-induced Ca2+ release and Ca2+- or caffeine-induced Ca2+ release from intracellular membrane systems.
1989,
Pubmed
Phillips,
Functions of angiotensin in the central nervous system.
1987,
Pubmed
Regoli,
Pharmacology of angiotensin.
1974,
Pubmed
Sandberg,
Angiotensin II-induced calcium mobilization in oocytes by signal transfer through gap junctions.
1990,
Pubmed
,
Xenbase
Sawada,
Intracellularly injected inositol hexakisphosphate induces a biphasic current in identified neurons of Aplysia.
1989,
Pubmed
Sealfon,
Gonadotropin-releasing hormone receptor expression in Xenopus oocytes.
1990,
Pubmed
,
Xenbase
Shapira,
Activation of two different receptors mobilizes calcium from distinct stores in Xenopus oocytes.
1990,
Pubmed
,
Xenbase
Singer,
Short- and long-term desensitization of serotonergic response in Xenopus oocytes injected with brain RNA: roles for inositol 1,4,5-trisphosphate and protein kinase C.
1990,
Pubmed
,
Xenbase
Snutch,
The use of Xenopus oocytes to probe synaptic communication.
1988,
Pubmed
,
Xenbase
Speth,
Identification of angiotensin II receptors in the rat ovary.
1986,
Pubmed
Sternweis,
Isolation of two proteins with high affinity for guanine nucleotides from membranes of bovine brain.
1984,
Pubmed
Stinnakre,
Cyclic adenosine monophosphate, calcium, acetylcholine and the current induced by adenosine in the Xenopus oocyte.
1986,
Pubmed
,
Xenbase
Sáez,
Hepatocyte gap junctions are permeable to the second messenger, inositol 1,4,5-trisphosphate, and to calcium ions.
1989,
Pubmed
Van Renterghem,
beta-Adrenergic induced K+ current in Xenopus oocytes: role of cAMP, inhibition by muscarinic agents.
1985,
Pubmed
,
Xenbase
Werner,
Translation and functional expression of cell-cell channel mRNA in Xenopus oocytes.
1985,
Pubmed
,
Xenbase