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XB-ART-23796
Comp Biochem Physiol Comp Physiol 1992 May 01;1021:7-14. doi: 10.1016/0300-9629(92)90003-9.
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Coupling between the intracellular pH and the active transport of sodium in an epithelial cell line from Xenopus laevis.

Chuard F , Durand J .


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1. The relationship between the rate of active Na+ transport and intracellular pH (pHi, measured as the BCECF fluorescence) was studied in A6 monolayers in the presence of CO2. The total buffering power (beta total) and its components (beta i and beta CO2) were assessed at various pHi. 2. The activity of Na+/H+ and Cl-/HCO3- exchangers were expressed in A6 cells; both antiports were found to participate in pHi homeostasis under standard conditions. 3. Alterations in the rate of Na+ transport induced variations in pHi. 4. Na+ transport rate was a hyperbolic function of external Na+ concentration. The curve was shifted by changing pHi: a mixed inhibition of Na+ transport by pHi was found. 5. The pHi appears as a possible mediator coupling the rate of Na+ transport across the apical and the basolateral membrane in tight epithelia.

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???displayArticle.link??? Comp Biochem Physiol Comp Physiol