XB-ART-23796
Comp Biochem Physiol Comp Physiol
1992 May 01;1021:7-14. doi: 10.1016/0300-9629(92)90003-9.
Show Gene links
Show Anatomy links
Coupling between the intracellular pH and the active transport of sodium in an epithelial cell line from Xenopus laevis.
???displayArticle.abstract???
1. The relationship between the rate of active Na+ transport and intracellular pH (pHi, measured as the BCECF fluorescence) was studied in A6 monolayers in the presence of CO2. The total buffering power (beta total) and its components (beta i and beta CO2) were assessed at various pHi. 2. The activity of Na+/H+ and Cl-/HCO3- exchangers were expressed in A6 cells; both antiports were found to participate in pHi homeostasis under standard conditions. 3. Alterations in the rate of Na+ transport induced variations in pHi. 4. Na+ transport rate was a hyperbolic function of external Na+ concentration. The curve was shifted by changing pHi: a mixed inhibition of Na+ transport by pHi was found. 5. The pHi appears as a possible mediator coupling the rate of Na+ transport across the apical and the basolateral membrane in tight epithelia.
???displayArticle.pubmedLink??? 1351827
???displayArticle.link??? Comp Biochem Physiol Comp Physiol