Click here to close Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly. We suggest using a current version of Chrome, FireFox, or Safari.
XB-ART-23491
Neuron 1992 Aug 01;92:209-16. doi: 10.1016/0896-6273(92)90160-f.
Show Gene links Show Anatomy links

Calcium-activated potassium channels expressed from cloned complementary DNAs.

Adelman JP , Shen KZ , Kavanaugh MP , Warren RA , Wu YN , Lagrutta A , Bond CT , North RA .


???displayArticle.abstract???
Calcium-activated potassium channels were expressed in Xenopus oocytes by injection of RNA transcribed in vitro from complementary DNAs derived from the slo locus of Drosophila melanogaster. Many cDNAs were found that encode closely related proteins of about 1200 aa. The predicted sequences of these proteins differ by the substitution of blocks of amino acids at five identified positions within the putative intracellular region between residues 327 and 797. Excised inside-out membrane patches showed potassium channel openings only with micromolar calcium present at the cytoplasmic side; activity increased steeply both with depolarization and with increasing calcium concentration. The single-channel conductance was 126 pS with symmetrical potassium concentrations. The mean open time of the channels was clearly different for channels having different substituent blocks of amino acids. The results suggest that alternative splicing gives rise to a large family of functionally diverse, calcium-activated potassium channels.

???displayArticle.pubmedLink??? 1497890
???displayArticle.link??? Neuron


Species referenced: Xenopus
Genes referenced: kcnma1