XB-ART-23439
Neurochem Int
1992 Sep 01;212:275-9. doi: 10.1016/0197-0186(92)90158-n.
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Expression of cloned aromatic L-amino acid decarboxylase in Xenopus laevis oocytes.
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Sense mRNA coding for bovine adrenal medulla aromatic L-amino acid decarboxylase (AADC) was expressed following microinjection into Xenopus laevis oocytes. The expressed enzyme activity was stereoselective for L-5-hydroxytryptophan and L-DOPA and blocked by NSD-1015 an inhibitor of AADC. Heating the expressed enzyme at 55 degrees C resulted in a parallel loss of activity towards both substrates. Our findings are consistent with the prevailing notion that a single enzyme is able to decarboxylate both substrates in vivo.
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