Click here to close Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly. We suggest using a current version of Chrome, FireFox, or Safari.
XB-ART-23097
Neurosci Lett 1992 Dec 07;1472:155-8. doi: 10.1016/0304-3940(92)90583-s.
Show Gene links Show Anatomy links

Suppression of a ligand operated membrane current by the epileptogenic agent pentylenetetrazol in oocytes of Xenopus laevis after injection of rat brain RNA.

Bloms P , Musshoff U , Madeja M , Müsch-Nittel K , Kuhlmann D , Spener F , Speckmann EJ .


???displayArticle.abstract???
The effects of the epileptogenic substance pentylenetetrazol (PTZ) on ligand operated membrane channels were studied. For this purpose serotonin (5-HT) sensitive channels were expressed in RNA injected oocytes of Xenopus laevis. With simultaneous application of both substances, the response to 5-HT was reduced and eventually abolished by PTZ with increasing concentrations (5-100 mM). A reduction of the 5-HT response also appeared when PTZ was applied in various intervals (15 and 240 s) before 5-HT. It may be assumed that PTZ produces a component of its epileptogenic effect by acting on ligand operated membrane channels.

???displayArticle.pubmedLink??? 1283455
???displayArticle.link??? Neurosci Lett