XB-ART-22969
J Neurochem
1993 Jan 01;601:299-304. doi: 10.1111/j.1471-4159.1993.tb05851.x.
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Morphine inhibits calcium influx and the response to acetylcholine in Xenopus oocytes.
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Incubation of intact Xenopus oocytes with the opioid radioligand [3H]diprenorphine (0.5 nM) resulted in specific binding of 1.7 +/- 0.3 fmol per oocyte. Morphine (10 microM) inhibited the uptake of 45Ca2+ into the oocyte by 66 +/- 9%. The opioid antagonist naltrexone partially blocked this effect of morphine. Preincubation of oocytes with morphine (10 microM, 2 min) partially inhibited the fast and slow responses of the oocyte to acetylcholine by 26 and 52%, respectively. We conclude that native Xenopus oocytes possess opioid receptors that may modulate the muscarinic response by limiting calcium influx into the cell.
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