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XB-ART-22730
Biochem Biophys Res Commun 1993 Mar 31;1913:1354-62. doi: 10.1006/bbrc.1993.1366.
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Cleavage arrest in Xenopus embryos injected with a human c-myc gene.

Miyata S , Tachibana K , Takano T , Asano M , Shiokawa K , Kihara HK .


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The c-myc protein has been implicated in cell proliferation and differentiation of various cell lines, but its function in early embryos of Xenopus is obscure. We introduced the c-myc gene into embryos using a pcDL-SR alpha plasmid with an efficient promoter of the gene. It was found that fertilized eggs injected with the c-myc gene were arrested at the 4-cell stage within 1 h of the injection, when the plasmid that carried c-myc gene but not the plasmid that carried defective c-myc gene was injected. These results also suggest that Xenopus embryos already have the ability to transcribe an exogenously injected c-myc gene at the 4-cell stage.

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Species referenced: Xenopus laevis
Genes referenced: myc