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XB-ART-22538
Pflugers Arch 1993 Jun 01;4241:91-3.
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Early effects of aldosterone on the basolateral potassium conductance of A6 cells.

Broillet MC , Berger A , Horisberger JD .


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Aldosterone increases the basolateral conductance in target epithelia. The basolateral membrane of tight epithelia contains two different types of K+ conductances (GK), a "resting" and a volume-activated GK. We have studied the early effects (at 4 hours) of 500 nmol/l aldosterone on the basolateral membrane GK of A6 cells (a Xenopus laevis kidney cell line), after the permeabilization of the apical membrane with amphotericin B. In the presence of a 97 to 3 mmol/l apical to basolateral K+ gradient, the "resting", inward rectifying GK was similar in control and aldosterone treated cells. In contrast, aldosterone induced a 2-fold increase of the volume-activated quinidine sensitive GK.

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References [+] :
Broillet, Basolateral membrane potassium conductance of A6 cells. 1991, Pubmed, Xenbase