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XB-ART-22505
FEBS Lett 1993 Jun 07;3241:63-6.
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Subunit-specific block of cloned NMDA receptors by argiotoxin636.

Raditsch M , Ruppersberg JP , Kuner T , Günther W , Schoepfer R , Seeburg PH , Jahn W , Witzemann V .


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Cloned NMDA receptor channels of the NR1-NR2A, NR1-NR2B and NR1-NR2C type show differences in argiotoxin636 block. Mutations of an asparagine residue located at a homologous position in the TM2 region of all NMDA receptor subunits, which corresponds to the Q/R site of the AMPA receptors, alters the argiotoxin636-induced block. The results suggest that the toxin interacts at this amino acid position with the putative pore forming TM2 region of the NMDA receptor subunits. Sequence differences in the TM2 segment of NR2A and NR2C subunits are not responsible for the subtype-specific sensitivity to argiotoxin636 as revealed by site-directed mutagenesis.

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Species referenced: Xenopus laevis
Genes referenced: grin1 grin2a grin2b grin2c nodal1