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XB-ART-22301
Eur J Pharmacol 1993 Aug 24;2402-3:213-7. doi: 10.1016/0014-2999(93)90901-s.
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Blocking effect of serotonin on beta-adrenoceptor activity in follicle-enclosed Xenopus oocytes.

Fujita R , Tamazawa Y , Barnard EA , Matsumoto M .


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The effects of serotonin (5-HT) on a beta-adrenergic response were studied, using the voltage clamp technique, in Xenopus laevis oocytes surrounded by their follicular cells. noradrenaline induced marked hyperpolarization, with a specific increase in the permeability of the membrane toward K+. Application of 10 microM 5-HT had little effect on the resting membrane, but significantly depressed the response to 0.1 microM noradrenaline. The dose-response curve for noradrenaline showed a parallel shift to the right in the presence of 5-HT, suggesting that 5-HT competes with noradrenaline for common binding sites at the beta-adrenoceptor.

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