Click here to close Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly. We suggest using a current version of Chrome, FireFox, or Safari.
XB-ART-22291
FEBS Lett 1993 Aug 30;3293:291-5.
Show Gene links Show Anatomy links

Cloning and expression of a cDNA for the rat kappa-opioid receptor.

Minami M , Toya T , Katao Y , Maekawa K , Nakamura S , Onogi T , Kaneko S , Satoh M .


???displayArticle.abstract???
We cloned a cDNA for the rat kappa-opioid receptor from a rat thalamus cDNA library. The deduced amino acid sequence consists of 380 residues with features shared by members of the G protein-coupled receptor family. The specific binding of [3H]bremazocine to the membrane of COS-7 cells transfected with the cDNA was displaced by kappa-specific opioid ligands, but not by mu- and delta-specific ligands. Xenopus oocytes injected with the in vitro transcribed mRNA responded to opioid ligands with the same subtype specificity. Northern blot analysis demonstrated that kappa-opioid receptor mRNA is expressed in a regionally specific manner in rat brain.

???displayArticle.pubmedLink??? 8103466
???displayArticle.link??? FEBS Lett