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Mol Biol Rep
1993 Oct 01;183:197-207. doi: 10.1007/bf01674431.
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Gene structure and alternative splicing of XFG 5-1, a X. laevis Zn finger protein with RNA homopolymer binding activity.
Köster M
,
Hille S
,
Pieler T
,
Knöchel W
.
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We describe the fine-structure of the Xenopus laevis XFG 5-1 gene which codes for an RNA homopolymer binding Zn finger protein of the FAR (Finger Associated Repeat) subfamily. The gene contains six exons, i.e., a leader exon (I), four exons (II-V), each of them encoding one individual copy of the FAR repeat, and one exon (VI) encoding the linker as well as the complete multifinger-region of the corresponding protein. Isolation and characterization of distinct cDNAs revealed that primary transcripts are alternatively spliced, thereby leading either to mRNAs containing different copy numbers of the FAR repeat or, by utilization of an alternative splice acceptor site in front of exon VI, to an extension of the linker region between the FAR repeats and the multifinger domain. We also describe the fine-structure of a closely related gene, termed XFG 5-2, which is located downstream to the XFG 5-1 gene. The general structural organization in both genes is identical, but point mutations should give rise to a XFG 5-2 protein with a different number of Zn finger units.
Baker,
Messenger RNA for the Ad2 DNA binding protein: DNA sequences encoding the first leader and heterogenity at the mRNA 5' end.
1979, Pubmed
Baker,
Messenger RNA for the Ad2 DNA binding protein: DNA sequences encoding the first leader and heterogenity at the mRNA 5' end.
1979,
Pubmed
Bellefroid,
The evolutionarily conserved Krüppel-associated box domain defines a subfamily of eukaryotic multifingered proteins.
1991,
Pubmed
,
Xenbase
Benoist,
In vivo sequence requirements of the SV40 early promotor region.
1981,
Pubmed
Bickmore,
Modulation of DNA binding specificity by alternative splicing of the Wilms tumor wt1 gene transcript.
1992,
Pubmed
Bordereaux,
Alternative splicing of the Evi-1 zinc finger gene generates mRNAs which differ by the number of zinc finger motifs.
1990,
Pubmed
DiBello,
The Drosophila Broad-Complex encodes a family of related proteins containing zinc fingers.
1991,
Pubmed
Ghosh,
Identification of a promoter component involved in positioning the 5' termini of simian virus 40 early mRNAs.
1981,
Pubmed
Grosschedl,
Identification of regulatory sequences in the prelude sequences of an H2A histone gene by the study of specific deletion mutants in vivo.
1980,
Pubmed
,
Xenbase
Haber,
Alternative splicing and genomic structure of the Wilms tumor gene WT1.
1991,
Pubmed
Hsu,
Multiple zinc finger forms resulting from developmentally regulated alternative splicing of a transcription factor gene.
1992,
Pubmed
Hummel,
Characterization of highly and moderately repetitive 500 bp Eco RI fragments from Xenopus laevis DNA.
1984,
Pubmed
,
Xenbase
Kessel,
Murine developmental control genes.
1990,
Pubmed
Knöchel,
Evolutionary conserved modules associated with zinc fingers in Xenopus laevis.
1989,
Pubmed
,
Xenbase
Krieg,
The mRNA encoding elongation factor 1-alpha (EF-1 alpha) is a major transcript at the midblastula transition in Xenopus.
1989,
Pubmed
,
Xenbase
Köster,
Structure, expression and in vitro functional characterization of a novel RNA binding zinc finger protein from Xenopus.
1991,
Pubmed
,
Xenbase
Köster,
The finger motif defines a multigene family represented in the maternal mRNA of Xenopus laevis oocytes.
1988,
Pubmed
,
Xenbase
Morishita,
Unique expression of the human Evi-1 gene in an endometrial carcinoma cell line: sequence of cDNAs and structure of alternatively spliced transcripts.
1990,
Pubmed
Nietfeld,
Evidence for a clustered genomic organization of FAX-zinc finger protein encoding transcription units in Xenopus laevis.
1993,
Pubmed
,
Xenbase
Nietfeld,
Second-order repeats in Xenopus laevis finger proteins.
1989,
Pubmed
,
Xenbase
Pöting,
Two different mRNAs coding for identical elongation factor 1 alpha (EF-1 alpha) polypeptides in Xenopus laevis embryos.
1990,
Pubmed
,
Xenbase
Read,
Alternatively spliced transcripts of the Drosophila tramtrack gene encode zinc finger proteins with distinct DNA binding specificities.
1992,
Pubmed
Rosati,
Members of the zinc finger protein gene family sharing a conserved N-terminal module.
1991,
Pubmed
,
Xenbase
Rosenfeld,
POU-domain transcription factors: pou-er-ful developmental regulators.
1991,
Pubmed
Schubiger,
The Vi element. A transposon-like repeated DNA sequence interspersed in the vitellogenin locus of Xenopus laevis.
1985,
Pubmed
,
Xenbase
Scott,
The structure and function of the homeodomain.
1989,
Pubmed
Spohr,
Structural analysis of a cDNA clone from Xenopus laevis containing a repetitive sequence element.
1982,
Pubmed
,
Xenbase
Spohr,
Organization and sequence analysis of a cluster of repetitive DNA elements from Xenopus laevis.
1981,
Pubmed
,
Xenbase
el-Baradi,
Zinc finger proteins: what we know and what we would like to know.
1991,
Pubmed
van Wijk,
Nuclear transport and phosphorylation of the RNA binding Xenopus zinc finger protein XFG 5-1.
1992,
Pubmed
,
Xenbase
