Riv Biol 2004 Jan 01;973:443-68.

Reaction-diffusion equations for simulation of calcium signalling in cell systems.

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Numerous experimental and theoretical studies have recently pointed to the importance of calcium signals and their propagation as waves of various kinds inside cells. This phenomenon has been particularly noted in fertilized egg cells. Ca2+ plays a fundamental role in these cells as it is capable of stimulating, by means of a first, large wave, the beginning of an organism's life at fertilization, immediately after sperm penetration. Furthermore, calcium is involved in numerous subsequent processes that are essential for the development of the future embryo, e.g. in contraction of cortical cytoplasm, protein synthesis and cell differentiation. Calcium waves, which are generated by self-oscillating pacemakers and propagate in excitable media, have been observed in some types of egg cells after fertilization. These waves adopt different shapes according to their emission frequency, wavelength, velocity and curvature, and they can occur as solitary waves, target waves or spiral waves. The mathematical models that study the progress of these waves have been developed by means of partial differential equations of the "reaction-diffusion" type. This study will discuss some significant models of intracellular Ca2+ dynamics. Some preliminary considerations will then be made in order to develop a model that describes the propagation of Ca2+ waves in ascidian eggs.

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