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Spatial localisation of transcripts of the Hox-C6 gene.
Shimeld SM
,
Gaunt SJ
,
Coletta PL
,
Geada AM
,
Sharpe PT
.
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The Hox-C6 gene, in common with its Xenopus and human homologues, is organised as 3 exons with 2 distinct promoters (PRI and PRII) producing 2 different transcripts. The PRII promoter produces a 'typical' Hox transcript by splicing 2 exons separated by a 700 bp intron. The PRI promoter initiates transcription from a 3rd exon, 9 kbp 5' of PRII. This exon is spliced into the 1st exon of the PRII transcript at a point 3' of the translation start codon. This means that the predicted protein product of the PRI protein contains the Hox-C6 homeodomain but is truncated by 82 amino acids compared with the PRII product. In situ hybridisation using probes specific for PRI or PRII showed them to have essentially the same distribution in the developing nervous system and prevertebrae of 12.5 d embryos. However, the distribution of transcripts in the CNS was distinctly different from that reported previously for a probe containing the Hox-C6 homeobox.
Awgulewitsch,
Deformed autoregulatory element from Drosophila functions in a conserved manner in transgenic mice.
1992, Pubmed
Awgulewitsch,
Deformed autoregulatory element from Drosophila functions in a conserved manner in transgenic mice.
1992,
Pubmed
Chisaka,
Regionally restricted developmental defects resulting from targeted disruption of the mouse homeobox gene hox-1.5.
1991,
Pubmed
Cho,
Differential utilization of the same reading frame in a Xenopus homeobox gene encodes two related proteins sharing the same DNA-binding specificity.
1988,
Pubmed
,
Xenbase
Coletta,
Characterisation of the murine Hox-3.3 gene and its promoter.
1991,
Pubmed
,
Xenbase
Dressler,
Anterior boundaries of Hox gene expression in mesoderm-derived structures correlate with the linear gene order along the chromosome.
1989,
Pubmed
Duboule,
A new homeo-box is present in overlapping cosmid clones which define the mouse Hox-1 locus.
1986,
Pubmed
,
Xenbase
Duboule,
The structural and functional organization of the murine HOX gene family resembles that of Drosophila homeotic genes.
1989,
Pubmed
Gaunt,
Mouse Hox-3.4: homeobox sequence and embryonic expression patterns compared with other members of the Hox gene network.
1990,
Pubmed
,
Xenbase
Geada,
Sequence and embryonic expression of the murine Hox-3.5 gene.
1992,
Pubmed
Graham,
Characterization of a murine homeo box gene, Hox-2.6, related to the Drosophila Deformed gene.
1988,
Pubmed
,
Xenbase
Graham,
The murine and Drosophila homeobox gene complexes have common features of organization and expression.
1989,
Pubmed
Graham,
The murine Hox-2 genes display dynamic dorsoventral patterns of expression during central nervous system development.
1991,
Pubmed
Izpisúa-Belmonte,
Expression of the homeobox Hox-4 genes and the specification of position in chick wing development.
1991,
Pubmed
Jegalian,
Homeotic transformations in the mouse induced by overexpression of a human Hox3.3 transgene.
1992,
Pubmed
Kessel,
Homeotic transformations of murine vertebrae and concomitant alteration of Hox codes induced by retinoic acid.
1991,
Pubmed
Kessel,
Respecification of vertebral identities by retinoic acid.
1992,
Pubmed
Le Mouellic,
Pattern of transcription of the homeo gene Hox-3.1 in the mouse embryo.
1988,
Pubmed
Lufkin,
Disruption of the Hox-1.6 homeobox gene results in defects in a region corresponding to its rostral domain of expression.
1991,
Pubmed
Malicki,
A human HOX4B regulatory element provides head-specific expression in Drosophila embryos.
1992,
Pubmed
Oliver,
Differential antero-posterior expression of two proteins encoded by a homeobox gene in Xenopus and mouse embryos.
1988,
Pubmed
,
Xenbase
Oudejans,
The three most downstream genes of the Hox-3 cluster are expressed in human extraembryonic tissues including trophoblast of androgenetic origin.
1990,
Pubmed
Savard,
Position dependent expression of a homeobox gene transcript in relation to amphibian limb regeneration.
1988,
Pubmed
,
Xenbase
Schughart,
Structure and expression of Hox-2.2, a murine homeobox-containing gene.
1988,
Pubmed
Scott,
Vertebrate homeobox gene nomenclature.
1992,
Pubmed
Sham,
Analysis of the murine Hox-2.7 gene: conserved alternative transcripts with differential distributions in the nervous system and the potential for shared regulatory regions.
1992,
Pubmed
Sharpe,
Isolation and expression of a new mouse homeobox gene.
1988,
Pubmed
,
Xenbase
Simeone,
At least three human homeoboxes on chromosome 12 belong to the same transcription unit.
1988,
Pubmed
Wright,
Interference with function of a homeobox gene in Xenopus embryos produces malformations of the anterior spinal cord.
1989,
Pubmed
,
Xenbase