XB-ART-21965
Cell Adhes Commun
1993 Dec 01;13:265-77. doi: 10.3109/15419069309097259.
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Sequence and distribution of Xenopus laevis E-cadherin transcripts.
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Cadherins are calcium-dependent adhesive glycoproteins implicated in histogenetic processes. In Xenopus laevis, the distribution of classical cadherins N, E, EP, XB and U has been determined by immunofluorescence labeling or by in situ hybridization. In this study, we report the full-length sequence of the E-cadherin cDNA. Comparison with the other cadherin sequences available indicates that Xenopus E-cadherin is as homologous to Xenopus EP-cadherin as to the chicken L-CAM and to the mammalian E-cadherin. Although Xenopus E-cadherin protein sequence exhibits many short conserved motifs present in other E-cadherins, it differs remarkably from the chicken L-CAM and the mammalian E-cadherin in its appearance after gastrulation. In situ hybridization data showed that E-cadherin transcripts are homogenously distributed in all differentiating epithelia from early tailbud to post-metamorphic stage. In contrast to mouse E-cadherin, Xenopus E-cadherin was not detected transiently in the nervous system during embryogenesis and in the post-metamorphic stages.
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Species referenced: Xenopus laevis
Genes referenced: cdh1