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The SLT2 (MPK1) MAP kinase homolog is involved in polarized cell growth in Saccharomyces cerevisiae.
Mazzoni C
,
Zarov P
,
Rambourg A
,
Mann C
.
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Bud emergence, spindle pole body duplication and DNA replication are all dependent on the activation of the CDC28 protein kinase at the Start point in the G1 phase of the cell cycle. Bud emergence requires polarization of the cytoskeleton and secretory vesicles to a specific site on the cell surface. Cdc28p activated by G1-cyclins triggers polarization of actin to the site of bud emergence and favors apical bud growth (Lew, D. J., and S. I. Reed. 1993. J. Cell Biol. 120:1305-1320). We isolated slt2-1 as a mutation that enhances the division defect of cdc28 mutants with defects at Start. Slt2p(Mpk1p) is a member of the MAP kinase family (Lee, K. S., K. Irie, Y. Gotoh, Y. Watanabe, H. Araki, E. Nishida, K. Matsumoto, and D. E. Levin. 1993. Mol. Cell. Biol. 13:3067-3075). We show that slt2 mutants exhibit phenotypes similar to those shown by mutants of the yeast actin cytoskeleton, including delocalization of chitin deposition and of actin cortical spots and the accumulation of secretory pathway membranes and vesicles. Furthermore, slt2::HIS3 act1-1 and slt2::HIS3 myo2-66 double mutants are inviable. We suggest that Slt2p functions downstream or in parallel with Cdc28p in promoting bud formation and apical growth.
Adams,
Requirement of yeast fimbrin for actin organization and morphogenesis in vivo.
1991, Pubmed
Adams,
Requirement of yeast fimbrin for actin organization and morphogenesis in vivo.
1991,
Pubmed
Amatruda,
Effects of null mutations and overexpression of capping protein on morphogenesis, actin distribution and polarized secretion in yeast.
1992,
Pubmed
Boeke,
A positive selection for mutants lacking orotidine-5'-phosphate decarboxylase activity in yeast: 5-fluoro-orotic acid resistance.
1984,
Pubmed
Bonneaud,
A family of low and high copy replicative, integrative and single-stranded S. cerevisiae/E. coli shuttle vectors.
1991,
Pubmed
Brewster,
An osmosensing signal transduction pathway in yeast.
1993,
Pubmed
Brockerhoff,
Calmodulin concentrates at regions of cell growth in Saccharomyces cerevisiae.
1992,
Pubmed
Cabib,
Synthesis of the yeast cell wall and its regulation.
1982,
Pubmed
Chant,
Budding and cell polarity in Saccharomyces cerevisiae.
1991,
Pubmed
Chant,
Genetic control of bud site selection in yeast by a set of gene products that constitute a morphogenetic pathway.
1991,
Pubmed
Chenevert,
A yeast gene (BEM1) necessary for cell polarization whose product contains two SH3 domains.
1992,
Pubmed
Costigan,
A synthetic lethal screen identifies SLK1, a novel protein kinase homolog implicated in yeast cell morphogenesis and cell growth.
1992,
Pubmed
Drubin,
Development of cell polarity in budding yeast.
1991,
Pubmed
Ducommun,
cdc2 phosphorylation is required for its interaction with cyclin.
1991,
Pubmed
,
Xenbase
Dunn,
Null alleles of SAC7 suppress temperature-sensitive actin mutations in Saccharomyces cerevisiae.
1990,
Pubmed
Errede,
A conserved kinase cascade for MAP kinase activation in yeast.
1993,
Pubmed
Gartner,
Signal transduction in Saccharomyces cerevisiae requires tyrosine and threonine phosphorylation of FUS3 and KSS1.
1992,
Pubmed
Haarer,
Purification of profilin from Saccharomyces cerevisiae and analysis of profilin-deficient cells.
1990,
Pubmed
Hartwell,
Genetic control of the cell division cycle in yeast.
1974,
Pubmed
Irie,
MKK1 and MKK2, which encode Saccharomyces cerevisiae mitogen-activated protein kinase-kinase homologs, function in the pathway mediated by protein kinase C.
1993,
Pubmed
Johnston,
The Saccharomyces cerevisiae MYO2 gene encodes an essential myosin for vectorial transport of vesicles.
1991,
Pubmed
Johnston,
Ribosomal precursor RNA metabolism and cell division in the yeast Saccharomyces cerevisiae.
1980,
Pubmed
Kilmartin,
Structural rearrangements of tubulin and actin during the cell cycle of the yeast Saccharomyces.
1984,
Pubmed
Kim,
Cellular morphogenesis in the Saccharomyces cerevisiae cell cycle: localization of the CDC3 gene product and the timing of events at the budding site.
1991,
Pubmed
Kosako,
cDNA cloning of MAP kinase kinase reveals kinase cascade pathways in yeasts to vertebrates.
1993,
Pubmed
,
Xenbase
Lee,
A yeast mitogen-activated protein kinase homolog (Mpk1p) mediates signalling by protein kinase C.
1993,
Pubmed
,
Xenbase
Lee,
Dominant mutations in a gene encoding a putative protein kinase (BCK1) bypass the requirement for a Saccharomyces cerevisiae protein kinase C homolog.
1992,
Pubmed
Levin,
Mutants in the S. cerevisiae PKC1 gene display a cell cycle-specific osmotic stability defect.
1992,
Pubmed
Lew,
Morphogenesis in the yeast cell cycle: regulation by Cdc28 and cyclins.
1993,
Pubmed
Liu,
Characterization of TPM1 disrupted yeast cells indicates an involvement of tropomyosin in directed vesicular transport.
1992,
Pubmed
Luna,
Cytoskeleton--plasma membrane interactions.
1992,
Pubmed
Madden,
Cell polarity and morphogenesis in Saccharomyces cerevisiae.
1992,
Pubmed
Madden,
Specification of sites for polarized growth in Saccharomyces cerevisiae and the influence of external factors on site selection.
1992,
Pubmed
Matsui,
Yeast RHO3 and RHO4 ras superfamily genes are necessary for bud growth, and their defect is suppressed by a high dose of bud formation genes CDC42 and BEM1.
1992,
Pubmed
Novick,
Phenotypic analysis of temperature-sensitive yeast actin mutants.
1985,
Pubmed
Novick,
Suppressors of yeast actin mutations.
1989,
Pubmed
Novick,
Order of events in the yeast secretory pathway.
1981,
Pubmed
Nurse,
Universal control mechanism regulating onset of M-phase.
1990,
Pubmed
Paravicini,
The osmotic integrity of the yeast cell requires a functional PKC1 gene product.
1992,
Pubmed
Pelech,
Mitogen-activated protein kinases: versatile transducers for cell signaling.
1992,
Pubmed
Piggott,
A bifunctional gene product involved in two phases of the yeast cell cycle.
1982,
Pubmed
Preuss,
Characterization of the Saccharomyces Golgi complex through the cell cycle by immunoelectron microscopy.
1992,
Pubmed
Pringle,
Immunofluorescence methods for yeast.
1991,
Pubmed
Pringle,
Fluorescence microscopy methods for yeast.
1989,
Pubmed
Reed,
Mitotic role for the Cdc28 protein kinase of Saccharomyces cerevisiae.
1990,
Pubmed
Reed,
The role of p34 kinases in the G1 to S-phase transition.
1992,
Pubmed
Rose,
A Saccharomyces cerevisiae genomic plasmid bank based on a centromere-containing shuttle vector.
1987,
Pubmed
Rothstein,
One-step gene disruption in yeast.
1983,
Pubmed
Sherman,
Getting started with yeast.
1991,
Pubmed
Sikorski,
A system of shuttle vectors and yeast host strains designed for efficient manipulation of DNA in Saccharomyces cerevisiae.
1989,
Pubmed
Simon,
Ras1 and a putative guanine nucleotide exchange factor perform crucial steps in signaling by the sevenless protein tyrosine kinase.
1991,
Pubmed
Snyder,
Studies concerning the temporal and genetic control of cell polarity in Saccharomyces cerevisiae.
1991,
Pubmed
Snyder,
The SPA2 protein of yeast localizes to sites of cell growth.
1989,
Pubmed
Staebell,
Temporal and spatial differences in cell wall expansion during bud and mycelium formation in Candida albicans.
1985,
Pubmed
Stettler,
A general suppressor of RNA polymerase I, II and III mutations in Saccharomyces cerevisiae.
1993,
Pubmed
Surana,
The role of CDC28 and cyclins during mitosis in the budding yeast S. cerevisiae.
1991,
Pubmed
Sutton,
The SIT4 protein phosphatase functions in late G1 for progression into S phase.
1991,
Pubmed
Tamemoto,
Biphasic activation of two mitogen-activated protein kinases during the cell cycle in mammalian cells.
1992,
Pubmed
Torres,
A protein kinase gene complements the lytic phenotype of Saccharomyces cerevisiae lyt2 mutants.
1991,
Pubmed
Wilson,
The Saccharomyces cerevisiae SRK1 gene, a suppressor of bcy1 and ins1, may be involved in protein phosphatase function.
1991,
Pubmed
