Click here to close
Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly.
We suggest using a current version of Chrome,
FireFox, or Safari.
Histochemistry
1994 Feb 01;1012:79-89. doi: 10.1007/bf00269353.
Show Gene links
Show Anatomy links
CD44 variant isoforms are preferentially expressed in basal epithelial of non-malignant human fetal and adult tissues.
Terpe HJ
,
Stark H
,
Prehm P
,
Günthert U
.
???displayArticle.abstract??? CD44 is a transmembrane glycoprotein, which can exist in a multitude of isoforms due to alternative splicing of the pre-mRNA. We have generated monoclonal antibodies to several of these variant regions, which are encoded by 10 additional exons in the extracellular part of the molecule. CD44 variant isoforms have been reported to be involved in the malignant progression of rat and human tumours. The precise localization of CD44 variant isoforms in normal developmental and morphogenetic processes is essential for diagnostic studies of human tumorigenesis. Therefore, we have analysed a large number of different human tissues by immunohistochemistry for the expression of CD44 isoforms containing either exons 4v, 6v or 9v. Expression of exon 9v-isoforms was detected in almost all epithelia analysed, with a few exceptions. Exon 6v isoforms are expressed only in squamous and glandular epithelial, e.g. skinepidermis, sweat and sebaceous glands, oesophagus, ducts of the mammary gland, salivary and prostate glands. Detection of exon 4v-encoded isoforms was restricted to the epidermis and the oesophagus. Similar tissue distributions of CD44 variant isoforms were observed in 10-week-old fetal tissues. Since one of the ligands of CD44 is hyaluronic acid (HA), we also analysed the tissue distribution of HA synthetase. HA synthetase was detected in all tissues analysed, showing good correlation with the expression of the standard form of CD44, CD44s.
Alho,
The hyaluronate receptor is preferentially expressed on proliferating epithelial cells.
1989, Pubmed
Alho,
The hyaluronate receptor is preferentially expressed on proliferating epithelial cells.
1989,
Pubmed
Banerjee,
Hyaluronan-binding protein in endothelial cell morphogenesis.
1992,
Pubmed
Cordell,
Immunoenzymatic labeling of monoclonal antibodies using immune complexes of alkaline phosphatase and monoclonal anti-alkaline phosphatase (APAAP complexes).
1984,
Pubmed
Fox,
CD44 and cancer screening.
1993,
Pubmed
Green,
Distribution of hyaluronate and hyaluronate receptors in the adult lung.
1988,
Pubmed
Günthert,
A new variant of glycoprotein CD44 confers metastatic potential to rat carcinoma cells.
1991,
Pubmed
Günthert,
CD44: a multitude of isoforms with diverse functions.
1993,
Pubmed
Haynes,
The transmembrane hyaluronate receptor (CD44): multiple functions, multiple forms.
1991,
Pubmed
Haynes,
CD44--a molecule involved in leukocyte adherence and T-cell activation.
1989,
Pubmed
Heider,
A human homologue of the rat metastasis-associated variant of CD44 is expressed in colorectal carcinomas and adenomatous polyps.
1993,
Pubmed
Heider,
Differential expression of CD44 splice variants in intestinal- and diffuse-type human gastric carcinomas and normal gastric mucosa.
1993,
Pubmed
Hofmann,
CD44 splice variants confer metastatic behavior in rats: homologous sequences are expressed in human tumor cell lines.
1991,
Pubmed
Jalkanen,
Lymphocyte CD44 binds the COOH-terminal heparin-binding domain of fibronectin.
1992,
Pubmed
Klewes,
The hyaluronate synthase from a eukaryotic cell line.
1993,
Pubmed
,
Xenbase
Koopman,
Activated human lymphocytes and aggressive non-Hodgkin's lymphomas express a homologue of the rat metastasis-associated variant of CD44.
1993,
Pubmed
Lesley,
CD44 and its interaction with extracellular matrix.
1993,
Pubmed
Mackay,
Characterization of a 95,000 molecule on sheep leucocytes homologous to murine Pgp-1 and human CD44.
1988,
Pubmed
Mackay,
Expression and modulation of CD44 variant isoforms in humans.
1994,
Pubmed
Matsumura,
Significance of CD44 gene products for cancer diagnosis and disease evaluation.
1992,
Pubmed
Mayer,
De-novo expression of CD44 and survival in gastric cancer.
1993,
Pubmed
Picker,
Monoclonal antibodies to human lymphocyte homing receptors define a novel class of adhesion molecules on diverse cell types.
1989,
Pubmed
Prehm,
Identification and regulation of the eukaryotic hyaluronate synthase.
1989,
Pubmed
,
Xenbase
Reber,
Retardation of metastatic tumor growth after immunization with metastasis-specific monoclonal antibodies.
1990,
Pubmed
Rudy,
The two major CD44 proteins expressed on a metastatic rat tumor cell line are derived from different splice variants: each one individually suffices to confer metastatic behavior.
1993,
Pubmed
Screaton,
Genomic structure of DNA encoding the lymphocyte homing receptor CD44 reveals at least 12 alternatively spliced exons.
1992,
Pubmed
Screaton,
The identification of a new alternative exon with highly restricted tissue expression in transcripts encoding the mouse Pgp-1 (CD44) homing receptor. Comparison of all 10 variable exons between mouse, human, and rat.
1993,
Pubmed
Seiter,
Prevention of tumor metastasis formation by anti-variant CD44.
1993,
Pubmed
Stamenkovic,
The hematopoietic and epithelial forms of CD44 are distinct polypeptides with different adhesion potentials for hyaluronate-bearing cells.
1991,
Pubmed
Tanabe,
Expression of CD44R1 adhesion molecule in colon carcinomas and metastases.
1993,
Pubmed
Turley,
Ras-transformed cells express both CD44 and RHAMM hyaluronan receptors: only RHAMM is essential for hyaluronan-promoted locomotion.
1993,
Pubmed
Underhill,
CD44: the hyaluronan receptor.
1992,
Pubmed
Wang,
Distribution of hyaluronan and its CD44 receptor in the epithelia of human skin appendages.
1992,
Pubmed
Wielenga,
Expression of CD44 variant proteins in human colorectal cancer is related to tumor progression.
1993,
Pubmed
