XB-ART-21588
Neurosci Lett
1994 Feb 14;1671-2:183-6. doi: 10.1016/0304-3940(94)91057-x.
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Effects of an activator and an inhibitor of protein kinase C on serotonin receptors induced by rat brain mRNA in Xenopus oocytes.
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The effects of bath-applied phorbol esters, protein kinase C (PKC) activators, and sphingosine, a PKC inhibitor, on membrane currents evoked by serotonin were studied in Xenopus oocytes injected with rat brain mRNA. The oscillatory Cl- current in response to bath-applied 50 nM serotonin was significantly depressed by 200 nM phorbol dibutyrate and remarkably augmented by 100 microM sphingosine. Both drugs have little effect either on the nonspecific Cl- current response induced by aluminum fluoride or on the cationic current response induced by 1 mM kainate.
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