XB-ART-21575
Biochim Biophys Acta
1994 Feb 23;11901:181-4.
Show Gene links
Show Anatomy links
Cooperative membrane insertion of magainin correlated with its cytolytic activity.
???displayArticle.abstract???
Using oriented circular dichroism, we have found that magainin adopts an alpha-helical conformation with two distinct orientations when interacting with a lipid bilayer. At low concentrations, magainin is absorbed parallel to the membrane surface. However, at high concentrations, magainin is inserted into the membrane. This transition occurs at roughly the same critical concentration required for cytolytic activity, implying that the membrane insertion is responsible for magainin's cell-lysing activity.
???displayArticle.pubmedLink??? 8110813
???displayArticle.link??? Biochim Biophys Acta
???displayArticle.grants???
Species referenced: Xenopus
Genes referenced: magainins