XB-ART-21563
Neurosci Lett
1994 Feb 28;1681-2:130-4. doi: 10.1016/0304-3940(94)90433-2.
Show Gene links
Show Anatomy links
A novel nicotinic agonist facilitates induction of long-term potentiation in the rat hippocampus.
???displayArticle.abstract???
Long-term potentiation (LTP) can be modulated by a number of neurotransmitter receptors including muscarinic and GABAergic receptor types. We have found that a novel nicotinic agonist, 2,4-dimethoxybenzylidene anabaseine (DMXB), facilitated the induction of LTP in the hippocampus in a dose-dependent and mecamylamine-sensitive manner. DMXB displaced high affinity nicotinic [125I]alpha-bungarotoxin and [3H]acetylcholine binding in rat brain. Xenopus oocyte studies demonstrated that DMXB has agonist activity at alpha 7 but not alpha 4/beta 2 nicotinic receptor subtypes. These results indicated that DMXB is a novel nicotinic agonist with apparent specificity for the alpha 7/alpha-bungarotoxin nicotinic receptor subtype and indicate that nicotinic receptor activation is capable of modulating the induction of long-term potentiation.
???displayArticle.pubmedLink??? 8028765
???displayArticle.link??? Neurosci Lett
???displayArticle.grants???