XB-ART-21351
Cancer Lett
1994 Apr 29;791:73-5. doi: 10.1016/0304-3835(94)90065-5.
Show Gene links
Show Anatomy links
A novel p53 mutant in human breast cancer revealed by multiple SSCP analysis.
???displayArticle.abstract???
DNA from tumor tissue and peripheral blood lymphocytes of primary breast cancer patients was screened for the presence of p53 mutations. In DNA from one tumor we found that the histidine codon 193 (CAT) was somatically converted to arginine (CGT). This amino acid residue is highly conserved in many species, thus suggesting that such mutation plays an important role in the loss of wt-p53 function.
???displayArticle.pubmedLink??? 8187056
???displayArticle.link??? Cancer Lett
Species referenced: Xenopus
Genes referenced: tp53