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XB-ART-21351
Cancer Lett 1994 Apr 29;791:73-5. doi: 10.1016/0304-3835(94)90065-5.
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A novel p53 mutant in human breast cancer revealed by multiple SSCP analysis.

Nigro V , Napolitano M , Abbondanza C , Medici N , Puca AA , Schiavulli M , Armetta I , Moncharmont B , Puca GA , Molinari AM .


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DNA from tumor tissue and peripheral blood lymphocytes of primary breast cancer patients was screened for the presence of p53 mutations. In DNA from one tumor we found that the histidine codon 193 (CAT) was somatically converted to arginine (CGT). This amino acid residue is highly conserved in many species, thus suggesting that such mutation plays an important role in the loss of wt-p53 function.

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Species referenced: Xenopus
Genes referenced: tp53