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Genetics
1994 Jun 01;1372:513-20. doi: 10.1093/genetics/137.2.513.
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A Drosophila third chromosome Minute locus encodes a ribosomal protein.
Andersson S
,
Saebøe-Larssen S
,
Lambertsson A
,
Merriam J
,
Jacobs-Lorena M
.
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Minutes (M) are a group of over 50 phenotypically similar Drosophila mutations widely believed to affect ribosomal protein genes. This report describes the characterization of the P element-induced M(3)95A(Plac92) mutation [allelic to M(3)95A]. This mutation can be reversed by the mobilization of the P element, demonstrating that the mutation is caused by insertion of this transposable element. The gene interrupted by insertion of the P element was cloned by use of inverse polymerase chain reaction. Nucleotide sequence analysis revealed a 70-75% identity to the human and rat ribosomal protein S3 genes, and to the Xenopus ribosomal protein S1a gene. At the amino acid level, the overall identity is approximately 78% for all three species. This is only the second time that a Minute has been demonstrated to encode a ribosomal protein.
Barrio,
Cloning and analysis of the S2 ribosomal protein cDNA from Drosophila.
1993, Pubmed
Barrio,
Cloning and analysis of the S2 ribosomal protein cDNA from Drosophila.
1993,
Pubmed
Baumgartner,
Drosophila ribosomal protein S19 cDNA sequence.
1993,
Pubmed
Broderick,
Localization of minutes to specific polytene chromosome bands by means of overlapping duplications.
1982,
Pubmed
Brown,
Ribosomal protein S14 is encoded by a pair of highly conserved, adjacent genes on the X chromosome of Drosophila melanogaster.
1988,
Pubmed
Burns,
Isolation and characterization of cloned DNA sequences containing ribosomal protein genes of Drosophila melanogaster.
1984,
Pubmed
Chan,
The primary structure of rat ribosomal protein S3.
1990,
Pubmed
,
Xenbase
Chooi,
Group fractionation and determination of the number of ribosomal subunit proteins from Drosophila melanogaster embryos.
1980,
Pubmed
Di Cristina,
Xenopus laevis ribosomal protein S1a cDNA sequence.
1991,
Pubmed
,
Xenbase
Dorer,
Ribosomal protein S14 is not responsible for the Minute phenotype associated with the M(1)7C locus in Drosophila melanogaster.
1991,
Pubmed
Espelund,
A simple method for generating single-stranded DNA probes labeled to high activities.
1990,
Pubmed
Fruscoloni,
Translational regulation of a specific gene during oogenesis and embryogenesis of Drosophila.
1983,
Pubmed
Hariharan,
Functional dissection of a mouse ribosomal protein promoter: significance of the polypyrimidine initiator and an element in the TATA-box region.
1990,
Pubmed
Henry,
High-level expression of the ribosomal protein L19 in human breast tumors that overexpress erbB-2.
1993,
Pubmed
Hultman,
Direct solid phase sequencing of genomic and plasmid DNA using magnetic beads as solid support.
1989,
Pubmed
Itoh,
The nucleotide sequence of a gene for a putative ribosomal protein S31 of Drosophila.
1989,
Pubmed
Itoh,
The nucleotide sequence of cDNA for a Drosophila ribosomal protein with homology to rat ribosomal protein S26.
1989,
Pubmed
Jakobsen,
Purification of mRNA directly from crude plant tissues in 15 minutes using magnetic oligo dT microspheres.
1990,
Pubmed
Kay,
Selective translational regulation of ribosomal protein gene expression during early development of Drosophila melanogaster.
1985,
Pubmed
Kay,
Identification and germline transformation of the ribosomal protein rp21 gene of Drosophila: complementation analysis with the Minute QIII locus reveals nonidentity.
1988,
Pubmed
Kongsuwan,
A Drosophila Minute gene encodes a ribosomal protein.
,
Pubmed
Lambertsson,
Cloning and characterization of variable-sized gypsy mobile elements in Drosophila melanogaster.
1989,
Pubmed
Levy,
Oligopyrimidine tract at the 5' end of mammalian ribosomal protein mRNAs is required for their translational control.
1991,
Pubmed
Maki,
The Drosophila melanogaster RPS17 gene encoding ribosomal protein S17.
1989,
Pubmed
McNabb,
Identification of a Drosophila protein similar to rat S13 and archaebacterial S11 ribosomal proteins.
1993,
Pubmed
Mount,
Splicing signals in Drosophila: intron size, information content, and consensus sequences.
1992,
Pubmed
Noselli,
The Drosophila melanogaster ribosomal protein L17A-encoding gene.
1992,
Pubmed
O'Kane,
Detection in situ of genomic regulatory elements in Drosophila.
1987,
Pubmed
Olson,
Drosophila acidic ribosomal protein rpA2: sequence and characterization.
1993,
Pubmed
Patel,
Generation of Minute phenotypes by a transformed antisense ribosomal protein gene.
1992,
Pubmed
Qian,
Structural analysis of the Drosophila rpA1 gene, a member of the eucaryotic 'A' type ribosomal protein family.
1987,
Pubmed
Qian,
Antisense ribosomal protein gene expression specifically disrupts oogenesis in Drosophila melanogaster.
1988,
Pubmed
Rafti,
Isolation and structural analysis of a ribosomal protein gene in D.melanogaster.
1988,
Pubmed
,
Xenbase
Ritossa,
On the redundancy of DNA complementary to amino acid tranfer RNA and its absence from the nucleolar organizer region of Drosophila melanogaster.
1966,
Pubmed
Sanger,
DNA sequencing with chain-terminating inhibitors.
1977,
Pubmed
Schultz,
The Minute Reaction in the Development of DROSOPHILA MELANOGASTER.
1929,
Pubmed
Sinclair,
Genetic and developmental analysis of a temperature-sensitive minute mutation of Drosophila melanogaster.
1981,
Pubmed
Spencer,
The nucleotide sequence of a cloned cDNA encoding ribosomal protein S6 from Drosophila melanogaster.
1993,
Pubmed
Stewart,
Mutations in the Drosophila gene encoding ribosomal protein S6 cause tissue overgrowth.
1993,
Pubmed
Vaslet,
Isolation and mapping of a cloned ribosomal protein gene of Drosophila melanogaster.
1980,
Pubmed
Vässin,
Genetic interactions in early neurogenesis of Drosophila melanogaster.
1985,
Pubmed
Voelker,
Molecular and genetic organization of the suppressor of sable and minute (1) 1B region in Drosophila melanogaster.
1989,
Pubmed
Watson,
Drosophila homolog of the human S6 ribosomal protein is required for tumor suppression in the hematopoietic system.
1992,
Pubmed
Wigboldus,
cDNA and deduced amino acid sequence of Drosophila rp21C, another 'A'-type ribosomal protein.
1987,
Pubmed
Wilson,
Cloning of the Drosophila ribosomal protein S3: another multifunctional ribosomal protein with AP endonuclease DNA repair activity.
1993,
Pubmed
Zhang,
Isolation of a cDNA encoding human 40S ribosomal protein s3.
1990,
Pubmed
