XB-ART-21061
FEBS Lett
1994 Jul 04;3481:89-92.
Show Gene links
Show Anatomy links
Neuromedin B receptor, expressed in Xenopus laevis oocytes, selectively couples to G alpha q and not G alpha 11.
???displayArticle.abstract???
G-proteins of the q family have been implicated as mediators of bombesin receptors action. We cloned Xenopus G alpha q and G alpha 11 and specifically disrupted the synthesis of either protein with selective antisense oligonucleotides. G alpha q antisense inhibited responses mediated by neuromedin B receptor (NMB-R) by 74%, though not by gastrin-releasing peptide receptor (GRP-R). G alpha 11 antisense had little effect on either GRP-R- or NMB-R-mediated responses. This suggests that NMB-R couples to G alpha q, and that GRP-R and NMB-R show distinct G-protein coupling preferences in the Xenopus oocyte.
???displayArticle.pubmedLink??? 8026589
???displayArticle.link??? FEBS Lett
Species referenced: Xenopus laevis
Genes referenced: gast gnaq grp grpr nmb nmbr