XB-ART-20946
Bioessays
1994 Aug 01;168:539-40. doi: 10.1002/bies.950160806.
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Borrowing thy neighbour's genetics: neural induction and a Brachyury mutant in Xenopus.
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A recent article by Rao exemplifies a number of new trends in developmental biology, both of technical strategy and approach to the problem of neural induction. Rao introduced into frog embryos a mutant form of a mesodermal gene, Brachyury, and caused ectopic neural differentiation. This essay traces the route from the original Brachyury mutation in mouse to the most likely conclusion of Rao's experiments--suggested previously--that neural fate is a default pathway.
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Species referenced: Xenopus laevis
Genes referenced: aoc2 tbxt