Eur J Pharmacol 1994 Aug 16;2683:305-9. doi: 10.1016/0922-4106(94)90054-x.

Vanadate-induced oscillatory inward Cl- currents in Xenopus laevis oocytes.

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Extracellularly applied sodium orthovanadate (30-3000 microM) evoked oscillatory inward Cl- currents in defolliculated Xenopus laevis oocytes. The current responses were attenuated by microinjection of EGTA into the oocytes and by treatment of the oocytes with pertussis toxin (2 micrograms/ml). The vanadate responses were not affected by preceding vanadate (1 mM) responses or an angiotensin II (200 nM) response, or by pre-application of atropine (5 microM). Intracellular injection of vanadate was ineffective. These results suggest that vanadate stimulates Ca2+ mobilization in Xenopus oocytes possibly by activating surface membrane receptors, which is coupled to pertussis toxin-sensitive G-protein.

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