Eur J Pharmacol 1994 Aug 16;2683:375-80. doi: 10.1016/0922-4106(94)90062-0.

Potentiation by insulin and insulin-like growth factor-1 of glibenclamide-sensitive K+ currents in follicle-enclosed Xenopus oocytes.

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Effects of insulin and IGF-1 (insulin-like growth factor-1) on K+ channel opener-induced/glibenclamide-sensitive K+ currents were studied using follicle-enclosed Xenopus oocytes. Both insulin (4 x 10(-9)-4 x 10(-6) M) and IGF-1 (4 x 10(-10)-4 x 10(-7) M) increased the cromakalim-induced K+ currents in a concentration-dependent manner. The current-facilitating effect of IGF-1 was about ten times as potent as that of insulin. Treatment of the oocyte with pertussis toxin (2 micrograms/ml) suppressed the current-potentiating effects of insulin and IGF-1 by about 60%. Although phenylarsine oxide (1-100 microM), a putative inhibitor of protein tyrosine phosphatase, also facilitated the K+ currents, the current enhancing effects were not affected by pertussis toxin. These results suggest that insulin and IGF-1 potentiate the glibenclamide-sensitive K+ current by activating IGF-1 receptor and that pertussis toxin-sensitive G-protein may be associated with these effects.

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Species referenced: Xenopus laevis
Genes referenced: ins