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Poly(ADP-ribose) polymerase: structural conservation among different classes of animals and its implications.
Uchida K
,
Miwa M
.
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Poly(ADP-ribose) polymerase cDNAs have been isolated from different classes of animals. Cloning of genes from lower eukaryotes has allowed us to investigate directly the biological functions of poly(ADP-ribosyl)ation in vivo. The conservation of specific regions among mammals, chicken, Xenopus laevis, and Drosophila melanogaster reveals the essential structural elements required for recognition of breaks in DNA and for catalytic activity. Cys, His and basic residues in the zinc-finger consensus region are conserved. The carboxyl terminal region corresponding to an NAD-binding domain is strongly conserved. The dinucleotide-binding consensus sequence and beta 1-alpha A-beta 2, Rossmann fold structure, and beta-sheet structures are completely conserved from mammals to insect. In Drosophila, a putative leucine-zipper motif has been identified, and other poly(ADP-ribose) polymerases also contain an alpha-helical, amphipathic structure in the auto-modification domain. In this article, we review the recent structural analyses of the functional domains of poly(ADP-ribose) polymerase in phylogenetically divergent species, and discuss the implications of structural conservation for its biological functions.
Alkhatib,
Cloning and expression of cDNA for human poly(ADP-ribose) polymerase.
1987, Pubmed
Alkhatib,
Cloning and expression of cDNA for human poly(ADP-ribose) polymerase.
1987,
Pubmed
Benjamin,
ADP-ribosylation in mammalian cell ghosts. Dependence of poly(ADP-ribose) synthesis on strand breakage in DNA.
1980,
Pubmed
Burtscher,
ADP-ribosyltransferase is highly conserved: purification and characterization of ADP-ribosyltransferase from a fish and its comparison with the human enzyme.
1987,
Pubmed
Burtscher,
Isolation of ADP-ribosyltransferase by affinity chromatography.
1986,
Pubmed
Burtscher,
ADP-ribosyltransferase from Helix pomatia. Purification and characterization.
1987,
Pubmed
Cherney,
cDNA sequence, protein structure, and chromosomal location of the human gene for poly(ADP-ribose) polymerase.
1987,
Pubmed
Garnier,
Analysis of the accuracy and implications of simple methods for predicting the secondary structure of globular proteins.
1978,
Pubmed
Gradwohl,
The second zinc-finger domain of poly(ADP-ribose) polymerase determines specificity for single-stranded breaks in DNA.
1990,
Pubmed
Huppi,
Sequence and organization of the mouse poly (ADP-ribose) polymerase gene.
1989,
Pubmed
Ikejima,
The zinc fingers of human poly(ADP-ribose) polymerase are differentially required for the recognition of DNA breaks and nicks and the consequent enzyme activation. Other structures recognize intact DNA.
1990,
Pubmed
Ittel,
Chicken poly(ADP-ribose) synthetase: complete deduced amino acid sequence and comparison with mammalian enzyme sequences.
1991,
Pubmed
Kameshita,
Antigenic determinant and interspecies cross-reactivity of a monoclonal antibody to poly(ADP-ribose) synthetase.
1985,
Pubmed
Kawaichi,
Multiple autopoly(ADP-ribosyl)ation of rat liver poly(ADP-ribose) synthetase. Mode of modification and properties of automodified synthetase.
1981,
Pubmed
Kurosaki,
Primary structure of human poly(ADP-ribose) synthetase as deduced from cDNA sequence.
1987,
Pubmed
Landschulz,
The leucine zipper: a hypothetical structure common to a new class of DNA binding proteins.
1988,
Pubmed
Mandel,
Purification and properties of calf thymus poly adenosine diphosphate ribose polymerase.
1977,
Pubmed
Ménissier-de Murcia,
Zinc-binding domain of poly(ADP-ribose)polymerase participates in the recognition of single strand breaks on DNA.
1989,
Pubmed
Needleman,
A general method applicable to the search for similarities in the amino acid sequence of two proteins.
1970,
Pubmed
O'Shea,
X-ray structure of the GCN4 leucine zipper, a two-stranded, parallel coiled coil.
1991,
Pubmed
Ohgushi,
Bovine thymus poly(adenosine diphosphate ribose) polymerase. Physical properties and binding to DNA.
1980,
Pubmed
Ozawa,
Isolation of cDNAs encoding the catalytic domain of poly(ADP-ribose) polymerase from Xenopus laevis and cherry salmon using heterologous oligonucleotide consensus sequences.
1993,
Pubmed
,
Xenbase
Rickwood,
Characterisation of poly(ADP-Rib) polymerase activity in nuclei from the slime mould Dictyostelium discoideum.
1979,
Pubmed
Rossmann,
Chemical and biological evolution of nucleotide-binding protein.
1974,
Pubmed
Saito,
Cloning of a full-length cDNA encoding bovine thymus poly(ADP-ribose) synthetase: evolutionarily conserved segments and their potential functions.
1990,
Pubmed
Schreiber,
The human poly(ADP-ribose) polymerase nuclear localization signal is a bipartite element functionally separate from DNA binding and catalytic activity.
1992,
Pubmed
Scovassi,
Structural analysis of poly(ADP-ribose)polymerase in higher and lower eukaryotes.
1986,
Pubmed
Simonin,
Expression and site-directed mutagenesis of the catalytic domain of human poly(ADP-ribose)polymerase in Escherichia coli. Lysine 893 is critical for activity.
1990,
Pubmed
Suzuki,
Molecular cloning of cDNA for human poly(ADP-ribose) polymerase and expression of its gene during HL-60 cell differentiation.
1987,
Pubmed
Thibodeau,
Cloning of rodent cDNA coding the poly(ADP-ribose) polymerase catalytic domain and analysis of mRNA levels during the cell cycle.
1989,
Pubmed
Uchida,
Isolation of the poly(ADP-ribose) polymerase-encoding cDNA from Xenopus laevis: phylogenetic conservation of the functional domains.
1993,
Pubmed
,
Xenbase
Uchida,
Cloning of cDNA encoding Drosophila poly(ADP-ribose) polymerase: leucine zipper in the auto-modification domain.
1993,
Pubmed
Uchida,
Nucleotide sequence of a full-length cDNA for human fibroblast poly(ADP-ribose) polymerase.
1987,
Pubmed
Ushiro,
Purification and characterization of poly (ADP-ribose) synthetase from human placenta.
1987,
Pubmed
Werner,
Presence of poly (ADP-ribose) polymerase and poly (ADP-ribose) glycohydrolase in the dinoflagellate Crypthecodinium cohnii.
1984,
Pubmed
